Preclinical Evaluation Of The Biodistribution, Biological Activity And Therapeutic Efficacy Of Recom

ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE
Organisation/Company ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE Research Field Medical sciences Neurosciences Pharmacological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 19 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The project will evaluate the biodistribution, biological activity and therapeutic efficacy of recombinant TAT?-CDKL5 protein in cellular and mouse models of CDKL5 Deficiency Disorder. Cellular studies will assess protein uptake, localization and persistence, together with effects on neuronal survival and maturation. Mouse studies will examine brain distribution, neuronal localization and pharmacodynamic responses to identify a dosing regimen for efficacy testing. Treatment effects will be assessed through behavioural testing and biochemical, histological and morphometric analyses, with particular attention to dendritic and synaptic alterations. Integrated findings will support the evaluation of the therapeutic potential of protein replacement therapy.
Italy
Eligibility of fellows: country/ies of residence:
All
Eligibility of fellows: nationality/ies:
Number of offers available 1 Company/Institute ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE Country Italy