Director, Drug Metabolism and Pharmacokinetics

4 settimane fa

Roma, Italia IRBM S.p.A. A tempo pieno
Director, Drug Metabolism and Pharmacokinetics (DMPK)

IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.

With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.

Job Description

We are currently seeking a motivated and experienced Director, Drug Metabolism and Pharmacokinetics (DMPK), who will have scientific oversight of and will manage the in vitro and in vivo PK, ADME and bioanalytical assays. The candidate will oversee and lead the activity of a team of more than 25 scientists who are responsible for the design, execution, analysis, interpretation and communication of PK/ADME studies to support drug development (small molecules, peptides, antibodies, novel modalities). This role’s responsibilities include developing and maintaining optimal organization within DMPK, as well as the scientific and managerial coordination of its groups and personnel. The successful candidate will optimize interdisciplinary activities within DMPK and integrate activities with those of the other R&D units and thus play a major role in shaping overall project and portfolio plans. In this role, the candidate will report directly to the CSO.

Key Responsibilities:

– Lead scientific efforts to characterize metabolic fate and pharmacokinetic properties of drug candidates (small molecules, peptides, antibodies and novel modalities) to inform and direct lead optimization of drug candidates; proactively identify issues and enable investigative efforts that further enhance optimization of drug candidates.

– Represent pre-clinical DMPK on cross-functional development project teams and with external partners for small molecule, peptides and antibody therapeutics, including preparing project strategies and development plans.

– Ensure that the DMPK team is current with emerging concepts and technologies so that these tools can be applied as appropriate for issues resolution.

– Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetic and in vitro ADME analyses of novel therapeutics.

– Oversee internal and outsourced pre-clinical drug metabolism and PK activities on multiple projects, including study design, data interpretation, report preparation.

– Provides strong scientific and strategic leadership, urgency, and business acumen to grow and progress IRBM mission in a speedy manner.

– Guides personnel goal setting to the most productive pursuit of shared goals and strategies.

– Supervising and managing a team of scientists by mentoring them, as well as providing expert advice and context for the interpretation of complex data.

– Manages personnel performance and develops career growth opportunities across DMPK.

– Desing and implement resourcing plans, draft-budgets, manages approved budgets and oversees hiring activities.

– Oversees regular review of staff deployment and project status, to ensure all projects are appropriately prioritized and resourced, and key goals and timelines are met.

– Balances degree of innovative exploration with pursuit of defined project objectives, and coordinates acquisition of new scientific capabilities, as appropriate

– Strong intellectual leadership, Capable of working autonomously and collaboratively in a multidisciplinary team setting.

– Strong verbal, written communication and relationship skills including success managing collaborations; track record of successful problem-solving, high-quality science and influencing of stakeholders, particularly in a drug project context.

– This position requires knowledge of PK/PD modeling to support IND-candidate selection and facilitate prediction of exposure required in humans.

Requirements:

– PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery, or a higher degree in a research area relevant to DMPK science.

– At least 8+ years of relevant industry experience.

During the job interview we will evaluate candidates’ experience and the job offer will be commensurate.

We thank all applicants for their interest, candidates selected for interviews will be contacted.

IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career.

#J-18808-Ljbffr

  • Deputy Director Office of Evaluation

    3 settimane fa

    Roma, Lazio, Italia Food and Agriculture Organization A tempo pieno

    Job DescriptionDescription –>The Food and Agriculture Organization of the United Nations (FAO) is the specialized Agency of the United Nations leading international efforts to defeat hunger. FAO works in over 130 countries worldwide to achieve food security for all and ensure that people have regular access to high-quality food.FAO contributes to the...

  • Marketing and Communication Property Director

    4 settimane fa

    Roma, Italia Anantara A tempo pieno

    Company Description A luxury hospitality brand for modern travellers, Anantara connects guests to genuine places, people and stories through personal experiences and providing heartfelt hospitality in the world’s most exciting destinations. From pristine islands and tropical beaches to cosmopolitan cities, tranquil deserts and lush jungles, Anantara...

  • Deputy Director Office of Evaluation

    1 mese fa

    Roma, Lazio, Italia Food and Agriculture Organization A tempo pieno

    Job DescriptionDescription –>The Food and Agriculture Organization of the United Nations (FAO) is the specialized Agency of the United Nations leading international efforts to defeat hunger. FAO works in over 130 countries worldwide to achieve food security for all and ensure that people have regular access to high-quality food.FAO contributes to the...

  • Deputy Director Office of Evaluation

    1 mese fa

    Roma, Lazio, Italia Food and Agriculture Organization A tempo pieno

    Job DescriptionDescription –>The Food and Agriculture Organization of the United Nations (FAO) is the specialized Agency of the United Nations leading international efforts to defeat hunger. FAO works in over 130 countries worldwide to achieve food security for all and ensure that people have regular access to high-quality food.FAO contributes to the...

  • Deputy Director, Land and Water Division

    1 mese fa

    Roma, Italia FAO A tempo pieno

    Job Posting: 27/Feb/2024 Closure Date: 26/Mar/2024, 5:59:00 PM Organizational Unit: Land and Water Division (NSL) **Job Type**: Staff position Type of Requisition: Senior-level Grade Level: D-1 Primary Location: Italy-Rome Duration: Fixed term: two years with possibility of extension Post Number: 0072575 CCOG Code: 1R01 - **FAO is committed to...

  • Deputy Regional Director East and Central Africa

    4 settimane fa

    Roma, Italia Intersos A tempo pieno

    **Job Title** Deputy Regional Director East and Central Africa Region **Code** SR-00-4794 **Deadline** 05/02/2023 **Country** Head Quarters **Duty Station** Rome **Starting date** 15/03/2023 **Contract duration** 12 months of which 4 months of probation **Reporting to** Regional Director East and Central Africa **Functional...

  • Director, Human Resources Division

    2 settimane fa

    Roma, Lazio, Italia FAO - Food and Agriculture Organization of the United Nations A tempo pieno

    Organizational SettingThe Food and Agriculture Organization of the United Nations (FAO) contributes to the achievement of the 2030 Agenda through the FAO Strategic Framework by supporting the transformation to MORE efficient, inclusive, resilient and sustainable agrifood systems, *for better production, better nutrition, a better environment* and *a better...

  • Associate Director Biostatistics

    4 settimane fa

    Roma, Italia Labcorp A tempo pieno

    **Associate Director Biostatistics, single-sponsor, home or office-based EMEA** Are you ready to discover your extraordinary potential at Labcorp Drug Development? A career here provides the unique chance to create a lasting impact and difference in patients’ lives. Joining our team will offer you a rewarding career, an opportunity to work in a...

  • Commercial Director

    1 settimana fa

    Roma, Italia Hilton Hotels Corporation A tempo pieno

    The Commercial Director, O&M EMEA is responsible for developing a commercial strategy covering all segments and channels to maximize total revenue and profit performance as well as market share penetration of the hotel.What will I be doing?The Commercial Director, O&M EMEA is responsible for developing a commercial strategy covering all segments and channels...

  • Director Global Facilities Operations

    1 mese fa

    Roma, Italia Thermo Fisher Scientific A tempo pieno

    **Director Global Facilities Operations**: - We are looking to fill this role in EMEA The Director Global Facilities Operations is responsible for leading and implementing the company’s Facilities Operations Programs globally. The Director will report directly to the VP Real Estate and Facilities. The Director acts as the Facilities Operations Director...

  • Sales Director

    3 giorni fa

    Roma, Italia Needle in a Haystack Ltd A tempo pieno

    Permanent, Full-Time, Day Shift Number of openings: 1 Remote Working **The Package - What you could earn**: - Basic salary negotiable depending on experience **Sales Director - Main Duties and Responsibilities**: - Travel across South Europe territory as required - Create and execute strategic plans to reach sales targets and expand customer base -...

  • Local Drug Safety Officer

    1 mese fa

    Roma, Italia Merck KGaA Darmstadt Germany A tempo pieno

    Work Your Magic with us! Ready to explore, break barriers, and discover more? We know you've got big plans - so do we! Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of...

  • Performance and Insights Associate Director

    1 mese fa

    Roma, Italia Bristol Myers Squibb A tempo pieno

    **Working with Us** Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms...

  • Strategic Capacity Director

    5 giorni fa

    Roma, Lazio, Italia Johnson & Johnson A tempo pieno

    Position Title: Strategic Capacity Director - Small Molecule E2E Locations: EMEA, North America Small Molecule sites Reports to: Senior Director - Strategic Capacity Planning Position Summary: The Strategic Capacity Director - Small Molecule E2E is responsible & accountable for developing and communicating long range strategic capacity analyses for a...

  • Deputy Regional Director for Emergencies

    4 settimane fa

    Roma, Italia Intersos A tempo pieno

    **Job Title** Deputy Regional Director for Emergencies **Code** SR-00-8328 **Deadline** 14/07/2023 **Country** Head Quarters **Duty Station** HQ Rome **Starting date** 01/08/2023 **Contract duration** 12 months **Reporting to** Regional Director for Emergencies **Functional Supervisor** Programme Coordinators in the AoR **Supervision...

  • Assistant Director of Finance

    1 mese fa

    Roma, Italia Hilton A tempo pieno

    The role aims to be recognized as trusted advisors in the hotel / hotels. This role supports the finance lead to attract and retains best-in-class finance professionals. This role assists in developing their finance team and enables them to Thrive. The role communicates with impact, ensures a robust control and compliance environment and supports to enable...

  • Digital Art Director Sr

    5 giorni fa

    Roma, Italia LATTE CREATIVE A tempo pieno

    **Location: Rome** Are you a highly skilled Art Director with a passion for designing impactful digital campaigns, services, and experiences? Latte Creative, working primarily with non-profit clients, is on the lookout for a versatile and experienced **Senior Art Director** to join our team. **About Us**: As **a team leader,** you will play a pivotal role...

  • Contract Logistics Director

    1 mese fa

    Roma, Italia Human Value A tempo pieno

    **Logista Italia **is the Italian subsidiary of Logista, the leading distributor of products and services to proximity retailers in Southern Europe. - Founded in 2004 following its acquisition by the Spanish group, Logista Italia has built one of the largest local logistics networks in Italy. Ongoing technological investment in innovation underpins every...

  • Summer Camp Director

    2 giorni fa

    Roma, Italia American Collegiate Adventures A tempo pieno

    Job Title: Summer Camp Director Become part of the American Collegiate Adventures (ACA) summer team! ACA is a summer pre-college enrichment program for high school and middle school students. Directors must be dedicated, responsible and flexible individuals who enjoy working hard in a high-energy environment. Directors receive invaluable training and...

  • Deputy Director, Office of Communications

    1 mese fa

    Roma, Italia FAO A tempo pieno

    Job Posting: 27/Feb/2024 Closure Date: 26/Mar/2024, 5:59:00 PM Organizational Unit: Office of Communications (OCC) **Job Type**: Staff position Type of Requisition: Senior-level Grade Level: D-1 Primary Location: Italy-Rome Duration: Fixed term: two years with possibility of extension Post Number: 2002610 CCOG Code: 1A - **FAO is committed to...