2026-IdrDip-05-medmol - Nuclear Signalling Compartmentalization in Skeletal Muscle Aging: the Role o

Organisation/Company Università di Pavia Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 25 Nov 2026 - 12:00 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description This project proposes the novel idea that the balance
between nuclear kinases and phosphatases is crucial for
skeletal muscle homeostasis during aging. To test this
hypothesis, the candidate will use different techniques and
novel tools (e.g., pooled optical CRISPR -FRET screenings,
nuclear-targeted biosensors, spatial proteomics of nuclei in
single fibers). The identification of new targets involved in
age-related nuclear dysfunction and the conceptual idea
that reframes sarcopenia as a nuclear signalling disorder,
will be important to advance the knowledge in the field of
aging.
The public call with detailed attendance and selection rules (Art 4 and 6) can be found at:
The selections are open to candidates, Italian or foreigner, in possession, on the date of the deadline for submitting applications for the admission to the selection, of a master's degree or single-cycle, preferably in Biotechnology - LM-9 degree program or a degree in Biological Sciences (LM-6),degree obtained no more than six years previously are eligible to participate in the selection process. These degrees must be relevant to the subject of the research activity.
Further specific assessable qualifications (see Art. 1 par. 1 Call for applications):
PhD,preferably in a biological or biomedical field. PhD thesis and Master's degree final grade. Experience in cell culture techniques, particularly with C2C12 myogenic cells,cell transfection, and isolation of skeletal muscle fibers.
Experience in FRET analysis, biochemical techniques for protein analysis, including electrophoresis and Western blotting, immunofluorescence, and fluorescence microscopy.

Experience in investigating second messenger signaling pathways, particularly cyclic AMP (cAMP) and Ca2+. Experience in the study of the equilibrium between kinases and phosphatases and their functional microdomains
AFRICA
EUROPE
OCEANIA
NORTH AMERICA
SOUTH AMERICA
ASIA
OTHER
Eligibility of fellows: country/ies of residence: AFRICA
EUROPE
OCEANIA
NORTH AMERICA
SOUTH AMERICA
ASIA
OTHER
Eligibility of fellows: nationality/ies: AFRICA
EUROPE
OCEANIA
NORTH AMERICA
SOUTH AMERICA
ASIA
OTHER
Selection process The application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carried out on the basis of qualifications and possible interview (with test of knowledge of the foreign language) (see Art. 1 par. 1 Call for applications).