Phenotypic impact of FXN gene splicing reprogramming in Friedreich Ataxia cells and mice
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Organisation/Company Università di Trento Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 25 Nov 2026 - 12:00 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
Friedreich Ataxia (FRDA) is a rare, progressive neurodegenerative disorder caused by a GAA trinucleotide repeat expansion in the first intron of the FXN gene, resulting in reduced expression of frataxin, a mitochondrial protein essential for iron-sulfur cluster biogenesis and cellular energy metabolism. Frataxin deficiency leads to mitochondrial dysfunction and progressive neurological and cardiac manifestations, with cardiomyopathy representing a major cause of morbidity and mortality. The research program aims to investigate the molecular and functional consequences of a novel therapeutic strategy designed to increase endogenous frataxin expression through reprogramming of FXN pre-mRNA alternative splicing. [...]
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Eligibility of fellows: country/ies of residence:
AFRICA
EUROPE
OCEANIA
NORTH AMERICA
SOUTH AMERICA
ASIA
OTHER
E.U.
CHINA (MAINLAND)
CHINA (HONG KONG)
Eligibility of fellows: nationality/ies:
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