Identification of Allosteric Modulators of Hemoglobin to Regulate the Oxygenation State for Treatmen

Organisation/Company Dipartimento di Chimica e tecnologie del farmaco Research Field Pharmacological sciences » Pharmacy Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 30 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description
The research project focuses on the development of a computational model for the selection of novel hemoglobin allosteric modulators, employing virtual binding studies targeting the allosteric site. Selected compounds will be evaluated for their hemoglobin inhibitory activity. The most promising candidates will undergo optimization through further virtual screening and chemical synthesis. These novel molecules will be re-evaluated for their activity on hemoglobin, and subsequent lead compounds will be tested on erythrocytes obtained from patients with sickle cell anemia.

Additional Information
Eligibility criteria

Italy

Eligibility of fellows: country/ies of residence:

EUROPE

Eligibility of fellows: nationality/ies: