Postdoc research associate
3 settimane fa
Posted Date: Dec 16 2024
Group B Streptococcus (GBS) is a major global cause of neonatal meningitis, sepsis and pneumonia, with an estimated 91,000 infant deaths per year and an additional 46,000 stillbirths. GBS infection in pregnancy is also associated with adverse maternal outcomes and preterm births. As such, the World Health Organization (WHO) prioritized the development of a GBS vaccine suitable for use in pregnant women and use in LMICs, where the burden of disease is highest. Current GBS vaccine candidates are either classical polysaccharide-conjugate vaccines or protein vaccines. Polysaccharide conjugates induce a suboptimal immune response in non primed women; however, they have a higher probability of success for the development of a correlate of protection. We propose to use Multiple Antigen Presenting System (MAPS) as an alternative technology that could combine advantages of polysaccharide-based vaccines, allowing also incorporation of pathogen-specific proteins.
The selected post-doc is expected to generate different MAPS by evaluating the most appropriate chemistry for all GBS polysaccharides to be included in the vaccine. She/he will characterize them, evaluate their purity, initial stability, and test them in animal models, comparing them with already available glycoconjugates.
Basic Qualifications & Skills:
- PhD qualification in chemistry or pharmaceutical chemistry and technology
- Experience in bacterial polysaccharide and glycoconjugate purification techniques like tangential flow filtration and chromatography (HIC, IEX, SEC)
- Experience in analysis and characterization of polysaccharides and glycoconjugates, using techniques like HPLC, HPAEC-PAD, NMR, and UV-VIS colorimetric methods
- Good level of spoken, conversational and written English
Preferred Qualifications & Skills:
- Experience with polysaccharide chemical derivatization
- Experience with polysaccharide conjugation chemistry
- Innovative thinking, able to identify links between different components of a problem or situation related to own work
- Clear and effective communication skills, oral and writing. Ability to present scientific data
- Experience with immunoassays and molecular biology (as a plus)
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology, and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged, and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
#J-18808-Ljbffr-
Clinical Research Associate
9 mesi fa
Siena, Italia Philochem AG A tempo pienoJob Title: CLINICAL RESEARCH ASSOCIATE - Location: Siena - Italy - Department: Clinical - Site initiation, monitoring, and close-out in accordance to GCP. - Monitoring visits and site management of national and European centres. - Tracking patient recruitment and enrollment. - Evaluating integrity and quality of patient data and investigator study file. - A...
-
Clinical Research Associate
2 settimane fa
Siena, Italia Philochem Ag A tempo pienoJob Title: CLINICAL RESEARCH ASSOCIATE- Location: Siena - Italy- Department: Clinical- Site initiation, monitoring, and close-out in accordance to GCP.- Monitoring visits and site management of national and European centres.- Tracking patient recruitment and enrollment.- Evaluating integrity and quality of patient data and investigator study file.- A good...
-
Postdoc Research Associate
3 settimane fa
Siena, Italia GSK A tempo pieno**Site Name**: Italy - Siena **Posted Date**: Dec 16 2024 The selected post-doc is expected to generate different MAPS, by evaluating the most appropriate chemistry for all GBS polysaccharides to be included in the vaccine. She/he will characterize them, evaluate their purity, initial stability and test them in animal models and compare them with already...
-
Postdoc Research Associate
3 settimane fa
Siena, Italia Glaxosmithkline A tempo pienoSite Name: Italy - SienaPosted Date: Dec 16 2024Group B Streptococcus (GBS) is a major global cause of neonatal meningitis, sepsis and pneumonia, with an estimated 91,000 infant deaths per year and an additional 46,000 stillbirths. GBS infection in pregnancy is also associated with adverse maternal outcomes and preterm births. As such, the World Health...
-
Postdoc Research Associate
3 settimane fa
Siena, Italia Glaxosmithkline A tempo pienoSite Name: Italy - SienaPosted Date: Dec 16 2024Group B Streptococcus (GBS) is a major global cause of neonatal meningitis, sepsis and pneumonia, with an estimated 91,000 infant deaths per year and an additional 46,000 stillbirths. GBS infection in pregnancy is also associated with adverse maternal outcomes and preterm births. As such, the World Health...
-
Postdoc Research Associate
3 settimane fa
Siena, Italia Gsk A tempo pieno**Site Name**: Italy - Siena**Posted Date**: Dec 16 2024The selected post-doc is expected to generate different MAPS, by evaluating the most appropriate chemistry for all GBS polysaccharides to be included in the vaccine. She/he will characterize them, evaluate their purity, initial stability and test them in animal models and compare them with already...
-
Postdoc Research Associate
4 settimane fa
Siena, Italia Gsk A tempo pieno**Site Name**: Italy - Siena**Posted Date**: Dec 12 2024Outer Membrane Proteins (OMPs) are a class of unique integral membrane proteins anchored in the Outer Membrane (OM) of Gram-negative bacteria. They represent about 2-3% of the total encoded bacterial genes and they consist of ß-barrel structures formed by 8 to 26 strands and by loops of various sizes....
-
Postdoc Research Associate
4 settimane fa
Siena, Italia GSK A tempo pieno**Site Name**: Italy - Siena **Posted Date**: Dec 12 2024 Outer Membrane Proteins (OMPs) are a class of unique integral membrane proteins anchored in the Outer Membrane (OM) of Gram-negative bacteria. They represent about 2-3% of the total encoded bacterial genes and they consist of β-barrel structures formed by 8 to 26 strands and by loops of various...
-
Postdoc Research Associate
4 ore fa
Siena, Italia Glaxosmithkline A tempo pienoSite Name: Italy - SienaPosted Date: Dec 12 2024Outer Membrane Proteins (OMPs) are a class of unique integral membrane proteins anchored in the Outer Membrane (OM) of Gram-negative bacteria.They represent about 2–3% of the total encoded bacterial genes and they consist of ß-barrel structures formed by 8 to 26 strands and by loops of various...
-
PostDoc Research Associate
21 ore fa
Siena, Italia GlaxoSmithKline A tempo pienoSite Name: Italy - SienaPosted Date: Dec 12 2024Outer Membrane Proteins (OMPs) are a class of unique integral membrane proteins anchored in the Outer Membrane (OM) of Gram-negative bacteria. They represent about 2–3% of the total encoded bacterial genes and they consist of β-barrel structures formed by 8 to 26 strands and by loops of various sizes....
-
Siena, Italia Sentcell Ltd A tempo pienoIn the compelling and unstoppable research in favor of cellular rejuvenation, Sentcell LTD is looking for a Master/PhD student or Junior Postdoc (the latter with Felasa Certificate) to investigate molecular mechanisms and innovative therapies at the basis of T cell and systemic rejuvenation.The studies will be held at our new laboratory located at the...
-
Clinical Trial Start Up Associate
6 giorni fa
Siena, Italia Bespoke Recruitment A tempo pienoJob location**:CORK, IRELAND _(relocation package available for those outside of Ireland)_** **Multinational pharmaceutical company in Cork, Ireland is looking for a **Clinical Trial Associate.** **You are**: - accountable to ensure the investigator sites meet requirements to enrol study participants into clinical trials and support ongoing activities...
-
Associate Scientist
4 mesi fa
Siena, Italia GSK A tempo pieno**Site Name**: Italy - Siena **Posted Date**: Sep 18 2024 We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work...
-
Clinical Trial Start Up Associate
13 ore fa
Siena, Italia Bespoke Recruitment A tempo pienoJob location**:CORK, IRELAND _(relocation package available for those outside of Ireland)_****Multinational pharmaceutical company in Cork, Ireland is looking for a **Clinical Trial Associate.****You are**:- accountable to ensure the investigator sites meet requirements to enrol study participants into clinical trials and support ongoing activities during...
-
Associate Scientist
4 settimane fa
Siena, Italia Gsk A tempo pieno**Site Name**: Italy - Siena**Posted Date**: Sep 18 2024We create a place where people can grow, be their best, be safe, and feel welcome, valued, and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.We embrace modern work...
-
Lead, Bioassay and Sample Management
3 mesi fa
Siena, Italia CSL Behring A tempo pienoThe Lead; Bioassay and Sample Management (L-BSM) is accountable for ensuring the on-time delivery of sample data and end-to-end central laboratory management across the global Clinical Development portfolio of CSL Clinical Trials. As the L-BSM you will establish CSL’s laboratory management strategy, processes and standards, support the selection and...
-
Lead, Bioassay And Sample Management
14 ore fa
Siena, Italia Csl Behring A tempo pienoThe Lead; Bioassay and Sample Management (L-BSM) is accountable for ensuring the on-time delivery of sample data and end-to-end central laboratory management across the global Clinical Development portfolio of CSL Clinical Trials.As the L-BSM you will establish CSL's laboratory management strategy, processes and standards, support the selection and oversees...