Design and chemical synthesis of small molecules as inhibitors of the different NADPH oxidase

Organisation/Company Sapienza Università di Roma Research Field Chemistry » Molecular chemistry Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 5 Oct 2026
- 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

This research focuses on the rational design, chemical synthesis, and optimization of small-molecule inhibitors targeting the different NADPH oxidase (NOX) isoforms. Activities include hit-to-lead optimization through structure–activity relationship (SAR) studies, rational drug design, and molecular modeling to improve potency, isoform selectivity, and drug‑like properties. The project also involves the multistep synthesis, purification, and structural characterization of novel compounds, followed by their biological evaluation to identify selective NOX inhibitors as potential therapeutic agents for oxidative stress‑related diseases.

• Italy

• EUROPE