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In vitro tests to predict the reactogenicity of RNA therapy drugs

2 settimane fa


Italia euraxess.ec.europa.eu - Jobboard A tempo pieno

Organisation/Company: Università degli studi di Messina

Research Field: Medical sciences, Biological sciences, Pharmacological sciences

Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)

Country: Italy

Application Deadline: 14 Jan 2025 - 12:00 (UTC)

Type of Contract: To be defined

Job Status: Not Applicable

Is the job funded through the EU Research Framework Programme? Not funded by a EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The described project focuses on one of the main obstacles to the development of RNA-therapy drugs, namely the innate immune response that recognizes these molecules as potential threats, triggering the production of type I interferons (IN I) and other pro-inflammatory cytokines. This response can cause severe side effects and reduce the drugs' efficacy. Therefore, there is an urgent need to develop methods that minimize these effects and provide a better understanding of the mechanisms underlying these reactions. The main objective of the project is to develop rapid human blood-based tests to predict the reactogenicity of experimental RNA-therapy drugs, enabling the selection of the safest drug candidates, hemodynamic, respiratory and metabolic function; Metabolic assessment by microdialysis of donor organs undergoing reconditioning.

Minimum Requirements

Master's/specialist/old system degree relating to the relevant scientific disciplinary area obtained in Italy or the equivalent qualification obtained abroad:

  • Degree Course in Medicine and Surgery (LM41)
  • Degree Course in Medical, Veterinary and Pharmaceutical Biotechnology (LM9)
  • Bachelor's Degree in Chemical, Biological, Pharmaceutical and Environmental Sciences (LM6)
  • Doctorate on subjects related to the topics of the research grant
Eligibility of Fellows

Country/ies of residence: EUROPE

Nationality/ies: EUROPE

Selection Process

The selection process will focus on RNA-therapy drugs, nucleic acid recognition by the innate immune system, and immune sensors in adverse drug reactions in RNA-based therapeutics.

Contact phone: 090 221 2252 - 090 221 3680

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