Overview Build the science that shapes the future of human health. Application closing date: . Join a place where ambitious science thrives. Human Technopole (Milan) is a rapidly expanding life science institute where international researchers and cutting-edge technologies converge to accelerate biomedical discovery. Our mission is to transform bold scientific ideas into advances that improve human health. Within this mission, the Legnini Group combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and optogenetics to engineer cells and organoids with the aim of reproducing complex regulatory cascades, then apply integrative transcriptomic readouts to understand the principles of gene regulation, particularly in neurodevelopment. At the same time, we use and develop high-throughput transcriptomic technologies and quantitative models to study mRNA regulation from synthesis to degradation. Your mission We are seeking an ambitious postdoc to study how genetic and environmental risk factors interact in the context of neural tube defects within HT\'s Flagship Research Programme Ciliopathies: an interdisciplinary, multi-scale approach involving multi-omic and structural analyses and advanced imaging techniques. The candidate will use stem-cell derived organoid models, genetic engineering, single-cell transcriptomics and imaging readouts to understand the mechanisms underlying specific congenital defects of neural tube morphogenesis. Grow Your Skills You will enhance your scientific and professional skills by working with: Human pluripotent stem cells and neural tube organoids Advanced transcriptomic technologies and computational genomics High-throughput imaging and optogenetics Human Technopole supports career development through training, mentoring and dedicated learning opportunities. Essential What you\'ll bring Holding a PhD in a life science discipline by the time of application or the position starting date Consolidated experience in mammalian cell culture, particularly pluripotent stem cells and organoids. Preferred Good knowledge of developmental biology Experience with single-cell transcriptomics techniques and analyses Experience with fluorescence imaging techniques and analyses At HT At HT, your discoveries contribute to a global effort to improve human health. Why Human Technopole HT offers an international and dynamic workplace, competitive welfare provisions, flexible working policies and relocation support. Researchers moving to Italy may benefit from attractive tax benefits. We promote work–life balance and provide parental support initiatives. Submit How to apply CV Motivation letter (English) Contact details of two referees This is a 3-year contract offered under CCNL Chimico Farmaceutico, Level B2. Salary: up to € 40.000,00 depending on the candidate’s seniority. The position is based in Milan, Italy, within our vibrant international campus. We strongly encourage applications from candidates belonging to protected categories (L. 68/99). The Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favor of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and/or obstructive circumstances. #J-18808-Ljbffr