Mitochondrial bioenergetic remodelling in cellular dysfunction: the role of F1Fo-ATPase and respiratory supercomplexes as targets for novel mitoprotective strategies

ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE MEDICHE VETERINARIE

Organisation/Company ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE MEDICHE VETERINARIE Research Field Chemistry » Biochemistry Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 9 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The research will identify and characterise synthetic and natural molecules capable of counteracting mitochondrial dysfunction by modulating F1FO-ATPase and preserving respiratory supercomplex organisation. Biochemical, kinetic and bioenergetic analyses in isolated mitochondria and cellular models will assess the effects of selected compounds on ATP synthesis and hydrolysis, mitochondrial respiration, membrane potential, ROS production and calcium homeostasis. Respiratory supercomplex assembly and susceptibility to mitochondrial permeability transition will also be investigated. The findings will help clarify the mechanisms of bioenergetic remodelling and identify novel mitoprotective strategies.

• Italy

Eligibility of fellows: country/ies of residence:

• All

Eligibility of fellows: nationality/ies:

Number of offers available 1 Company/Institute ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE MEDICHE VETERINARIE Country Italy