Scientist I, Process and Analytical Development
3 settimane fa
Design, develop, and implement workflows for mRNA production.
Uses a data-driven approach to progress development deliverables.
Develop robust and scalable downstream processes at the laboratory scale for the purification of nucleic acids with tangential flow filtration and liquid chromatography.
Perform troubleshooting process performance issues.
Support scale-up of upstream/downstream processes and technology transfer to the cGMP manufacturing and quality control groups for clinical material production.
Perform routine bench work under limited supervision, effectively prioritize responsibilities and complete assignments in a timely manner.
Able to analyze, interpret, and present results to project teams and write technical reports.
Maintaining domain expertise in new technologies and scientific literature to constantly drive innovation.
Qualifications: 4+ years of relevant experience in the industry or 3+ years of relevant experience in the industry.
Training in Biochemistry/Chemistry/Chemical engineering/Molecular biology or related scientific subject areas with proven experience.
Requirements:
Demonstrated experience with standard analytical equipment (plate reader, nanodrop, spectrophotometer, PCR, protein and nucleic acid electrophoresis) and knowledge of molecular biology, biochemistry, and biophysics protocols is required.
Strong technical expertise in two or more of the following: in vitro transcription (IVT) synthesis, molecular cloning, capillary gel electrophoresis (CGE) high-performance liquid chromatography (HPLC), fast protein liquid chromatography (FPLC), and tangential flow filtration (TFF).
Experience in upstream processing, including use of bioreactors at small, intermediate, and large scales; familiarity with the process development of mRNA products would be a plus.
Experience writing content for technical documentation, including SOPs, work instructions, technical protocols and reports, and technical presentations.
A high level of commitment and a track record of quality work, with attention to detail.
Capable of communicating the work clearly among the team.
A self-starter and great teammate.
Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. A one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory at Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.
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Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pienoJob DescriptionWe are seeking two highly motivated candidates for the role of Junior Scientists in the mRNA Process, Analytical and LNP Formulation Development team in Monza (Italy). The candidates shall have strong ability in upstream/downstream process development and are expected to work in a fast-paced environment with high self-motivation. The Junior...
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Monza, Italia Thermo Fisher Scientific A tempo pieno**Responsibilities**: - Develop and implement scalable mRNA purification strategies, to generate highly pure material. - Design, develop, and implement workflows for mRNA production. - Uses a data-driven approach to progress development deliverables. - Develop robust and scalable downstream processes at the laboratory scale for the purification of nucleic...
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Monza, Italia Thermo Fisher Scientific A tempo pieno: Develop and implement scalable mRNA purification strategies, to generate highly pure material. Design, develop, and implement workflows for mRNA production. Uses a data-driven approach to progress development deliverables. Develop robust and scalable downstream processes at the laboratory scale for the purification of nucleic acids with tangential...
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