In Vivo Respiratory Translational Pharmacology Senior Scientist

1 settimana fa

BOLOGNA, Italia Buscojobs A tempo pieno

Who we are looking for
Purpose
We are seeking a highly motivated and passionate scientist to contribute to our mission in delivering novel therapies for the treatment of chronic respiratory diseases such as asthma, COPD, and ILDs. The selected candidate will join our in vivo pharmacology and translational team focused on supporting discovery and translational research activities aimed at characterizing novel therapeutic targets and advancing discovery programs to the clinic.
Main Responsibilities
Independently design, conduct and analyze experiments to support the identification and/or advancement of clinical candidates, contributing to achieve project goals under tight timelines.
Design, execute and analyze key in vivo pharmacology experiments to validate potential therapeutic targets and understand the biology of novel targets/pathways.
Develop and validate novel in vivo models and readouts for respiratory disorders.
Set up and/or perform assays aimed to demonstrate target engagement and the biological effect through multi-omic approaches of our compounds.
Design, coordinate and monitor external studies at CROs.
Manage multiple projects simultaneously, and work in a fast-paced, cross-functional, and highly collaborative team environment.
Act as in vivo subject matter expert in project team meetings.
Collaborate with colleagues in other preclinical departments such as DMPK and chemistry, as well as other functional areas such as clinical and business development.
Provide updates at the different research committees and senior management, prepare research reports and peer-reviewed manuscripts, and contribute to the preparation of regulatory documents and patent filings.
Work closely with academic collaborators and outside entities to advance research needs.
Stay informed with emerging literature and science in respiratory research.
Experience Required
At least 3 years of relevant industry experience leading and executing preclinical research for drug discovery.
Education
PhD degree in biology, immunology, pharmacology or related discipline.
Languages
Fluent in English; Italian is not mandatory.
Technical Skills
Demonstrated hands-on experience in in vivo models (experience in respiratory disease models is preferred) to test disease hypotheses and assess drug effects, including certification for in vivo experimentation and animal welfare.
Hands-on experience in cellular, biochemical, histological, and molecular biology assay techniques (i.e. ELISA, MSD, multi-color flow cytometry, quantitative RT-PCR) in addition to transcriptomics and multi-omics approaches.
Knowledge and hands-on experience in studying inflammatory signaling pathways associated with chronic lung disease.
Knowledge of common software applications such as Microsoft Office (Excel, PowerPoint, Word) and data analysis software (e.g. GraphPad Prism).
Soft Skills
Scientific passion and entrepreneurial spirit.
Ability to work effectively in a multidisciplinary team environment.
Strong organizational skills, self-motivation, flexibility, and proactive willingness.
Self-awareness and desire to develop your skills further.
Ability to work in a team-oriented environment and good communication skills.
What we offer
You would join a dynamic, fast-growing, challenging, and friendly environment.
In Chiesi, we firmly believe that our people are our most valuable asset. That is why we invest in continuous training, learning, and development. Therefore, we strive to continuously promote and satisfy development needs, paying particular attention to the quality of our working environment and to collective well-being.
We want our people to come to work happy every day, and we know how important it is to find the right work-life balance in order to be able to give our best. That is why we offer a flexible working approach, remote working, support in the relocation process, tax assistance service for foreign colleagues, and many other people-care services.

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