Director, Drug Metabolism And Pharmacokinetics

3 settimane fa

Lazio, Italia Irbm S.P.A. A tempo pieno

Director, Drug Metabolism and Pharmacokinetics (DMPK) IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.
With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.
Job Description We are currently seeking a motivated and experienced Director, Drug Metabolism and Pharmacokinetics (DMPK), who will have scientific oversight of and will manage the in vitro and in vivo PK, ADME and bioanalytical assays. The candidate will oversee and lead the activity of a team of more than 25 scientists who are responsible for the design, execution, analysis, interpretation and communication of PK/ADME studies to support drug development (small molecules, peptides, antibodies, novel modalities). This role's responsibilities include developing and maintaining optimal organization within DMPK, as well as the scientific and managerial coordination of its groups and personnel. The successful candidate will optimize interdisciplinary activities within DMPK and integrate activities with those of the other R&D units and thus play a major role in shaping overall project and portfolio plans. In this role, the candidate will report directly to the CSO.
Key Responsibilities: – Lead scientific efforts to characterize metabolic fate and pharmacokinetic properties of drug candidates (small molecules, peptides, antibodies and novel modalities) to inform and direct lead optimization of drug candidates; proactively identify issues and enable investigative efforts that further enhance optimization of drug candidates.
– Represent pre-clinical DMPK on cross-functional development project teams and with external partners for small molecule, peptides and antibody therapeutics, including preparing project strategies and development plans.
– Ensure that the DMPK team is current with emerging concepts and technologies so that these tools can be applied as appropriate for issues resolution.
– Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetic and in vitro ADME analyses of novel therapeutics.
– Oversee internal and outsourced pre-clinical drug metabolism and PK activities on multiple projects, including study design, data interpretation, report preparation.
– Provides strong scientific and strategic leadership, urgency, and business acumen to grow and progress IRBM mission in a speedy manner.
– Guides personnel goal setting to the most productive pursuit of shared goals and strategies.
– Supervising and managing a team of scientists by mentoring them, as well as providing expert advice and context for the interpretation of complex data.
– Manages personnel performance and develops career growth opportunities across DMPK.
– Desing and implement resourcing plans, draft-budgets, manages approved budgets and oversees hiring activities.
– Oversees regular review of staff deployment and project status, to ensure all projects are appropriately prioritized and resourced, and key goals and timelines are met.
– Balances degree of innovative exploration with pursuit of defined project objectives, and coordinates acquisition of new scientific capabilities, as appropriate
– Strong intellectual leadership, Capable of working autonomously and collaboratively in a multidisciplinary team setting.
– Strong verbal, written communication and relationship skills including success managing collaborations; track record of successful problem-solving, high-quality science and influencing of stakeholders, particularly in a drug project context.
– This position requires knowledge of PK/PD modeling to support IND-candidate selection and facilitate prediction of exposure required in humans.
Requirements: – PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery, or a higher degree in a research area relevant to DMPK science.
– At least 8+ years of relevant industry experience.
During the job interview we will evaluate candidates' experience and the job offer will be commensurate.
We thank all applicants for their interest, candidates selected for interviews will be contacted.
IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career.
#J-18808-Ljbffr

  • Director, Drug Metabolism And Pharmacokinetics

    2 settimane fa

    Lazio, Italia Irbm S.P.A. A tempo pieno

    Director, Drug Metabolism and Pharmacokinetics (DMPK) IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.With a...

  • Nonclinical Safety And Dmpk- Senior Scientist

    2 settimane fa

    Lazio, Italia Antal International Network A tempo pieno

    As a Senior Scientist Nonclinical safety and Drug Metabolism and Pharmacokinetics, you will provide support to ongoing and planned nonclinical programs at early and late stage of drug development.This position is open to hybrid working arrangements, however candidates with remote work arrangement will be considered.ResponsabilityLead non-clinical ADME and PK...

  • Senior Director/Executive Director, Global Regulatory Affairs-Emea

    2 settimane fa

    Lazio, Italia Eli Lilly And Company A tempo pieno

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...

  • Senior Drug Safety Manager

    2 settimane fa

    Lazio, Italia Jr Italy A tempo pieno

    col-wideJob Description:We are experts in the Life Sciences industry & Technology.We are a long-standing partner for technology and expert service provider across Clinical, Regulatory, Quality, Pharmacovigilance and Medical Affairs domains.We help companies to gain the best business value through technology-enabled solutions and achieve excellence in...

  • Senior Drug Safety Specialist

    1 giorno fa

    Lazio, Italia Arithmos A tempo pieno

    Job Description About the Company:Arithmos is a leading international Company that operates within the Life Sciences industry & Technology field and establishes itself as a long-standing partner for technology and expert service providers across Clinical, Regulatory, Quality, Pharmacovigilance, and Medical Affairs domains.The role:We are currently looking...

  • Senior Director

    2 settimane fa

    Lazio, Italia The Jewish Board Of Children And Family Services A tempo pieno

    The Jewish Board of Children and Family Services Senior Director New York , New York Apply Now Make a bigger difference WORKING WITH US At The Jewish Board, we don't just make a difference - we make a bigger difference as we serve 45,000 New Yorkers every year.Join our dedicated team that's been helping communities across New York City for almost 150 years...

  • Sales Director

    1 mese fa

    Lazio, Italia Italian Jobs Hub A tempo pieno

    We are searching for a brilliant Sales Director to join our amazing team at ITALIAN JOBS HUB in Roma. Growing your career as a Full Time Sales Director is a terrific opportunity to develop useful skills. If you are strong in teamwork, leadership and have the right drive for the job, then apply for the position of Sales Director at ITALIAN JOBS HUB...

  • Strategic Capacity Director

    1 mese fa

    Lazio, Italia Johnson And Johnson A tempo pieno

    Position Title: Strategic Capacity Director - Small Molecule E2E Locations: EMEA, North America Small Molecule sites Reports to: Senior Director - Strategic Capacity Planning Position Summary: The Strategic Capacity Director - Small Molecule E2E is responsible & accountable for developing and communicating long range strategic capacity analyses for a select...

  • Director, Regulatory Affairs

    2 settimane fa

    Lazio, Italia Alnylam Pharmaceuticals Inc. A tempo pieno

    Job Description - Director, Regulatory Affairs U.S. Advertising and Promotion (USAP) (230626)Director, Regulatory Affairs U.S. Advertising and Promotion (USAP) ( Job Number: 230626 )The Director for U.S. Advertising and Promotion (USAP) will provide strategic regulatory advice to internal stakeholders regarding tactics and communications related to Alnylam's...

  • Director, Regulatory Affairs

    2 settimane fa

    Lazio, Italia Jr Italy A tempo pieno

    col-wideJob Description:Job Description - Director, Regulatory Affairs U.S. Advertising and Promotion (USAP) (230626)Director, Regulatory Affairs U.S. Advertising and Promotion (USAP) ( Job Number: 230626 )The Director for U.S. Advertising and Promotion (USAP) will provide strategic regulatory advice to internal stakeholders regarding tactics and...

  • Associate Director, Program Management

    2 settimane fa

    Lazio, Italia Alnylam Pharmaceuticals Inc. A tempo pieno

    Job Description - Associate Director, Program Management (240010)Associate Director, Program Management ( Job Number: 240010 )OverviewAt Alnylam, all clinical-stage development programs are managed by a Global Program Leadership Team, led by a Program Leader and a Program Manager, responsible for harnessing cross-functional expertise to define the best...

  • Communications Director

    1 mese fa

    Lazio, Italia International Refugee Assistance Project, Inc. A tempo pieno

    International Refugee Assistance Project, Inc. Communications Director New York , New York Apply Now Communications Director needed by International Refugee Assistance Project, Inc. in New York, NY to be responsible for leading Communication department's global efforts to develop and implement communications strategy, in line with strategic plan and...

  • Director

    1 mese fa

    Lazio, Italia Pjt Partners Holdings Lp A tempo pieno

    PJT Partners Holdings LP Director New York, New York Apply Now PJT Partners Holdings LP seeks Director in New York, NY to lead the day-to-day execution of transactions, including due diligence, valuation analysis, and the negotiating of contracts and other agreements. Requirements: Bachelor's degree or foreign equivalent in Finance, Economics, or a related...

  • Director

    1 mese fa

    Lazio, Italia Pjt Partners Holdings Lp A tempo pieno

    PJT Partners Holdings LP Director New York , New York Apply Now PJT Partners Holdings LP seeks Director in New York, NY to lead the day-to-day execution of transactions, including due diligence, valuation analysis, and the negotiating of contracts and other agreements. Requirements: Bachelor's degree or foreign equivalent in Finance, Economics, or a related...

  • Industrial Post-Doctoral Position In Molecular Dynamics And Virtual Screening

    1 giorno fa

    Lazio, Italia Rdp Pharma Ag A tempo pieno

    We are seeking a highly motivated and skilled Post-Doctoral Researcher to join our dynamic team in the field of Molecular Dynamics and Virtual Screening. The successful candidate will contribute to cutting-edge research in drug discovery and molecular simulations, with a focus on utilizing computational methods to identify potential drug candidates in...

  • Account Director

    2 settimane fa

    Lazio, Italia Jr Italy A tempo pieno

    col-wideJob Description:Situation Group Account Director New York , New York Apply Now Situation, a digital-first agency building passionate communities for live experience-based clients like WICKED on Broadway and The Metropolitan Opera, seeks Account Director to lead the day to day marketing and advertising strategy for some of our high profile Broadway...

  • Two 2-Year Postdoctoral Positions: University Of Torino And Candiolo Cancer Institute, Italy

    1 giorno fa

    Lazio, Italia Two Ocean A tempo pieno

    Home Postdoc Abroad Two 2-Year Postdoctoral Positions: University of Torino and Candiolo Cancer Institute, ItalyTwo 2-Year Postdoctoral Positions: Join the Department of Oncology at the University of Torino and the Candiolo Cancer Institute, Italy, as a Postdoctoral Research Fellow in the Translational Cancer Genetics laboratory of Prof. Sabrina Arena, PhD....

  • Deputy Director-General

    2 settimane fa

    Lazio, Italia Fao A tempo pieno

    • FAO is committed to achieving workforce diversity in terms of gender, nationality, background and culture• Qualified female applicants, qualified nationals of non-and under-represented Members and persons with disabilities are encouraged to apply• Everyone who works for FAO is required to adhere to the highest standards of integrity and professional...

  • Medical And Regulatory Affairs Director

    2 settimane fa

    Lazio, Italia Scelte Strategiche A tempo pieno

    Dettagli PropostaPosizione: Medical and Regulatory Affairs DirectorAzienda: Multinazionale FarmaceuticaLuogo di lavoro: MilanoScelte Strategiche is seeking a Medical & Regulatory Affairs Director for a pharmaceutical multinational company (job location: Milan).Purpose of the positionTo ensure, within Corporate and company strategic and management policies,...

  • Project Director

    1 settimana fa

    Lazio, Italia City Of New York A tempo pieno

    City of New York Project Director New York , New York Apply Now Work Location: 30-30 Thomson Avenue, NY, 11101Only candidates who are permanent in the Administrative Construction Project Manager title or those who filed for the Promotional Exam #3523, or the Open-Competitive Exam #3039 may apply. Please include a copy of your Receipt of Filing card or...