Postdoc in Crispr Meta-analytics for Therapeutic

1 settimana fa

Milano, Italia Human Technopole A tempo pieno

**APPLICATION CLOSING DATE: April 6th, 2024**

**Human Technopole (HT) **is an interdisciplinary life science research institute, created and supported by the Italian government, with the aim of developing innovative strategies to improve human health. HT is composed of five centres: Computational Biology, Structural Biology, Genomics, Neurogenomics, and Health Data Science. The Centres work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.

**About the lab**

Situated in the Computational Biology Research Centre of HT**, **the Iorio Lab operates at the intersection of biology, machine learning, statistics, and information theory. Our goal is to comprehend and predict how genomic alterations and molecular traits, derived from various omics, contribute to pathological processes, rewire biological circuits, and influence therapeutic responses in human cancers and other diseases.

Together with researchers at EMBL - European Bioinformatics Institute and Wellcome Sanger Institute, our lab has recently been awarded an Open Targets Research Grant funding the _OT Perturbation Catalogue_ project.

The project focuses on the creation of an online repository of data from functional genetics screens and, more generally, post-perturbational experiments (typically CRISPR screens with viability or transcriptomics readouts). We will focus on a specific meta-analytics work package of the OT Perturbation Catalogue project, developing computational methods for the reproducibility assessment1, harmonisation2 and analysis of inter-study CRISPR datasets, aggregating data and developing and using innovative therapeutic target prioritisation pipelines3 on the resulting aggregated data for cancer4, neurodegenerative disorders and other diseases.

HT benefits from accessibility to the HT National Facility for Genomics, providing state-of-the-art and innovative services ranging from high-throughput sequencing to multi-omics technologies.

**Key **Tasks and **Responsibilities**:

- Gathering existing cancer functional genomics and dependency map datasets, which are periodically revamped, in combination with the data already deposited in the OT Perturbation Catalogue, implementing methods for their comparisons and integration;
- Using existing computational pipelines and designing novel methods for computational meta-analysis of CRISPR datasets; for the aggregation and harmonisation of multiple inter-study CRISPR screens;
- Refining existing anti-cancer therapeutic target prioritisation pipelines and designing novel ones, then executing them on harmonised cancer-related perturbation data;
- Investigating how the developed methods could be extended to neurodegeneration and other diseases of interest, beyond cancer.
- Interacting with the other teams involved in the project across participating institutes, periodically presenting advances and results to Open Targets meetings and Integration days.

**Essential requirements**
- Hands-on experience in data science, preferably life sciences or medicine
- Proven track record demonstrating the ability to lead projects independently.
- Experience in the analysis of genomics or functional-genomics datasets.
- Fluency in English - HT is an international research institute.

**Preferred requirements**
- Experience with the analysis of data from CRISPR-Cas9 screens, siRNA, shRNA, antisense oligonucleotides (ASOs) or similar technologies
- Experience with handling large-scale datasets.
- Familiarity with cancer genomics
- Familiarity with the Cancer Dependency Map and portfolio of tools and resources

**Organizational and social skills**
- Ability to interact effectively with other teams and work synergistically to drive projects forward.
- Proven communication, team building and problem-solving skills.

**Application Instructions**

i) a CV

ii) a motivation letter in English

iii) names and contacts of 2 referees

**Additional Information**

The remuneration package is internationally competitive and comprises a highly competitive salary, pension scheme, medical and other social benefits and support for relocation and installation. The contract is for 3 years with the possibility of a 2-year extension.

HT offers a highly collaborative, international culture to foster top quality, interdisciplinary research by promoting a vibrant environment consisting of independent research groups with access to outstanding graduate students, postdoctoral fellows and core facilities.

HT is an inclusive employer that fosters diversity and engages systematically to ensure that equal employment opportunities are provided without regard to age, race, creed, religion, sex, disability, medical condition, sexual orientation, gender identity or expression, national or ethnic origin or any other legally recognized status entitled to protection under applicable laws. HT offers attractive conditi

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