Postdoc Pigino Group
3 settimane fa
**APPLICATION CLOSING DATE: 24 June 2024**
**Human Technopole (HT) **is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.
**About the lab**:
The Pigino Lab works right at the interface between structural and molecular cell biology, combining the latest methodologies from the respective fields, but always with a strong emphasis on cryo-electron microscopy, correlative light and electron microscopy, fluorescence microscopy and 3D image processing. We study the structure the function and the assembly process of cilia, ubiquitous eukaryotic organelles with fundamental motility, signalling and sensing functions. We study motile and primary cilia from unicellular model organisms such as Chlamydomonas reinhardtii, mammalian cell lines, organoids and tissues from mice and human pancreas, brain and kidney.
**See previous work on the research topics of this call**:
Ciliary microtubule doublets are heavily decorated by microtubule-associated proteins (MAPs), microtubule inner proteins (MIPs), and tubulin post-translational modifications (PTMs) in a highly organized manner. We have recently shown that tubulin PTMs form nano-patterns in cilia that specialize individual protofilaments for specific functions. With this project we will use a variety of light and electron microscopy techniques to investigate how tubulin PTMs enzymes are regulated to specifically modify individual microtubules tubule or even a single protofilament thereof during the initial growth of the axoneme or in the face of tubulin exchange during ciliary maintenance.
Alvarez Viar, Pigino. 2024. Tubulin posttranslational modifications through the lens of new technologies. DOI: 10.1016/j.ceb.2024.102362
Gadadhar et al., 2021. Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. doi: 10.1126/science.abd4914
**Key tasks and responsibilities**:
- Investigate the regulation of tubulin modifying enzymes in cilia.
- Establish or develop methods to achieve the research goals.
- Present the results of related scientific work in lab meetings and seminars within the Human Technopole and at international meetings.
- Generate reliable data for publication and record experimental information, data and results in specified forms (electronic notebook provided by HT).
- Contribute to the writing of manuscripts and to the preparation of related material for paper publication.
- Assist in the training of PhD students and contribute to the smooth running of the lab.
**Essential requirements**:
- PhD (or submitted PhD thesis) in Biology, Molecular Cell Biology, Structural Biology, or Physical Biology.
- Experience in imaging in fluorescence microscopy (TIRF microscopy, confocal microscopy, single molecule), protein purification, in vitro assays, image analysis (Fiji), coding (MATLAB and/or Python).
- Fluency in English.
**Preferential requirements**:
- Photopatterning.
- Experience in supervision of Master’s students.
**Application Instructions**
To apply, please send the following:
- a CV.
- a motivation letter in English relating your track record to the specifics of the call.
- names and contacts of 2 referees.
**Why Human Technopole**:
HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.
Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.
We believe that highly diverse teams yield the best and most innovative results.
We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.
**Main benefits**
- Welfare plans.
- Canteen service.
- Work-life balance provisions.
- Italian language training for foreigners.
- Parental leave up to 1 year and other support for new parents.
- Counseling.
- Flexible working hours.
- Remote working policy.
- Support for relocation.
- Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits.
**Number of positions offered: 1**
Contract offered: CCNL Chimico Farmaceutico, Fixed-term 4 years - employee level.
The position is based in Milan.
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