Postdoc in Targeted Drug Delivery

4 settimane fa

Milano, Italia Human Technopole A tempo pieno

**APPLICATION CLOSING DATE: 14th of March 2024**

Human Technopole (HT) is an interdisciplinary research institute in Milan (Italy) created and supported by the Italian government to develop innovative strategies to promote human health. HT adopts a multidisciplinary and integrated approach combining genomics, computational and structural biology, neuroscience, and data and decision sciences.

The** Zerial Group** works on endocytosis - from its molecular mechanisms to implications in cell and tissue organisation. Its interests range from the assembly and functional characterisation of the endosomal fusion machinery to establishing hepatocyte cell polarity and liver tissue structure and function. The Group uses a unique interdisciplinary approach combining biochemical and biophysical methods with advanced light microscopy, cell biology and computer-aided three-dimensional tissue reconstruction to develop novel targeted oligonucleotide therapeutics.

Specific targeting and endosomal escape remain crucial hurdles for the successful implementation of macromolecular therapeutics. The know-how in endocytosis positions the Zerial Group at the leading edge of understanding what drives these limitations and identifying novel ways to overcome these obstacles.

**Key tasks and responsibilities**
- Conduct in vivo imaging studies using quantitative light microscopy to monitor the trafficking and distribution of antibody-oligonucleotide conjugates in cells and mouse models.
- Compare the uptake efficiency between different cell lines and primary cells, providing insights into the potential variations in cellular uptake.
- Generate reliable data for publication and record all data and results in specified forms (paper and electronic).
- Contribute to the writing of project-related scientific papers.
- Assist in the training of PhD students and contribute to the smooth running of the lab.

**Mandatory requirements**:

- A PhD in life sciences.
- Documented prior experience in antibody or oligonucleotide modification or organic synthesis of biomolecules, ideally in antibody conjugation approaches.
- Proficiency in biochemistry and molecular biology methods and protein purification, quantification and detection techniques.
- Fluency in English.

**Preferred requirements**:

- A background in membrane biology, endocytosis and cell trafficking would be advantageous.
- Previous experience in quantitative light microscopy.

**Organizational and social skills**:

- Ability to work independently as well as in a team.
- Ability to work in a multi-cultural, multi-ethnic environment with sensitivity and respect for diversity.
- Ability to manage competing priorities in a fast-paced environment.
- Ability to build trust by operating transparently and creating an open and positive environment.
- Excellent communication skills and self-motivation.

**Application Instructions**

i) a CV
ii) a motivation letter in English
iii) names and contacts of at least 2 referees

**Why Human Technopole**
- HT seeks **scientific excellence**. We recruit the best scientific talents through international open calls.
- Our working environment is** international, friendly and inclusive**. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skill sets and methodological approaches.
- We believe that highly **diverse teams yield the best and most innovative results**.
- We engage in outward-facing scientific activities for the national and international research community. **Training** is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.

**Main benefits**
- Welfare plans.
- Canteen service.
- Work-life balance provisions.
- Italian language training for foreigners.
- Maternity leave up to 1 year and other support for new parents.
- Counseling.
- Flexible working hours.
- Remote working policy.
- Support for relocation.

**Number of positions offered**: 1
**Contract offered**: CCNL Chimico Farmaceutico, Fixed-term - 4 years - employee level.
The position is based in Milan

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