Post-doc Bioinfromatician

Località: Rozzano, IT, 20089

**Job title Post-Doc Bioinfromatician**

Within the _National Recovery and Resilience Plan (PNRR)_, the IRCCS Humanitas Research Hospital has started public selection processes for recruitment in the context of projects aimed at **enhancing and strengthening biomedical research within the National Health Service (SSN).**

**Project: Early diagnosis of high-grade serous epithelial ovarian cancer through the analysis of DNA derived from Pap Test smear (rif interno KMN314 - CUP: E23C24000310006)**

Early diagnosis of ovarian cancer through the analysis of Pap test DNA. Preliminary results from a recent study (Paracchini, Mannarino, et al. Science translational Medicine, 2023) have demonstrated the possibility to intercept genomic instability, a specific hallmark of ovarian cancer, in the DNA extracted from Pap test smears of women that would have developed cancer in the subsequent years. Through this approach it is possible to quantify the overall genomic instability by assessing the copy number profile abnormality (CPA). When the CPA is more than 0.61, it indicates the presence of tumor DNA. In order to increase the performance of this test in terms of sensitivity, specificity and accuracy, an improvement of the approach is needed. The underlying hypothesis is that not only genomic instability is a marker of the presence of the tumor, but that there are other molecular features such as DNA methylation that contribute to tumor detection. A multi-level omic approach and the clinical features of patients could be informative and can contribute in the improvement of the test.

**Professional profile and brief description of the required activities**:
**Post-Doc** (phd’s, post doc, tecnico, data analyst, medico, data manager, ecc)

**Activities**:
**Required qualifications**:

- Master’s degree in bioinformatics/engineering/physics/mathematics/biotechnology or equivalent.
- PhD in biomedical sciences/life science/biotechnology or equivalent.

**Technical skills**:

- Good knowledge of Python, R, Bash. Knowledge of Git and containers (Docker, Singularity);
- Good knowledge of workflow languages (nextflow);
- Knowledge of high-performance computing (HPC) systems;
- Good knowledge of machine learning approaches.

**Preferred requirements**:

- Documented experience in collaborating on open-source projects.
- Knowledge of written and spoken English (B2)
- Excellent communication skills
- Ability to work in a team.
- Open Position (published): 10/09/2024_
- End Published: 10/10/2024_