Post-doctoral Position in 3D Chromatin Architecture
2 settimane fa
**Post-doctoral position in 3D chromatin architecture and non-coding RNAs**
- (2300005Z)- Commitment & contract: collaboration contract_
**WHO WE ARE**
At IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society. Our Genoa headquarter is strictly inter-connected with our 11 centers around Italy and two outer-stations based in the US for a truly interdisciplinary experience.
**YOUR TEAM**
You will be working in a multicultural group, where computational scientists and molecular biologists collaborate, each with their own expertise, to carry out a scientific activity with a shared research goal.
We aim to understand how non-coding elements (DNA/RNA) and their epigenetic/epitranscriptomics modifications regulate 3D genome architecture and gene expression in stem cells and cancer models. To address this question, we use cutting-edge chromatin conformation assays such as Hi-C, Hi-ChIP and Pore-C in conjunction with other -omics techniques (e.g. ChIP-seq, TT-seq, scRNA-seq) and in combination with CRISPR-based genetic and epigenetic engineering tools. The final goal is to understand how ncRNAs can induce and/or maintain 3D promoter-enhancer contacts, which ultimately determines the transcriptional program that dictates stemness and tumorigenesis.
Within the team, your main responsibilities will be:
- Perform experiments in the area of 3D chromatin conformation, stem cells, non-coding RNAs and epitranscriptomics.
- Use advanced molecular biology techniques for the manipulation of chromatin, RNA, DNA and proteins.
- Assist in generating preliminary data and figures for grant proposals
- Supervise and mentor junior members of the team
**WHAT WOULD MAKE YOU SHINE**
- A PhD in Biology including Molecular Biology, Biochemistry or Genetics
- Previous experience in stem cell culture and advanced molecular biology techniques
- Knowledge of NGS technologies, including but not limited to CHIP-seq, RNA-seq, ATAC-seq etc
- A strong publication record
- Excellent command in spoken and written English
**EXTRA AWESOME**
- Experience in 3D chromatin conformation assays (e.g. Hi-C and Hi-ChIP etc)
- Previous research experience in RNA biology (non-coding RNAs is a plus)
- Ability to perform genomic and epigenomic editing techniques in stem cells using CRISPR-(d)Cas technologies
- Ability to work in a challenging and international environment
- Ability to work independently and collaboratively in a highly interdisciplinary environment
**COMPENSATION & BENEFITS**
- Competitive salary package for international standards
- Private health care coverage
- Wide range of staff discounts
**WHAT’S IN FOR YOU?**
- An equal, inclusive and multicultural environment ready to welcome you with open arms. Discrimination is a big NO for us
- We like collaboration and encourage you to mingle and discover what other people are up to in our labs
- If paperwork is not your piece of cake, we got you There’s a specialized team working to help you with that, especially during your relocation
- If you are a start upper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations.
- If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society
- We stick to our values Integrity, courage, societal responsibility and inclusivity are the values we believe in They define us and our actions in our everyday life. They guide us to accomplish IIT mission
If you feel this tickles your appetite for change, do not hesitate and apply
**Application’s deadline: October 31**st** 2023**
- We inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia._
- Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security._
**Primary Location** GENOVA ERZELLI
**Job** Postdoc
**Organization** 3D Chromatin Conformation and RNA Genomics
**Job Posting** Aug 1, 2023, 7:29:55 AM
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