Researcher - Pnrr Moh

Job offer

Research position for 24 months in the field of biomarkers discovery in frailty.

Job Location

IRCCS MultiMedica, Polo Scientifico e Tecnologico, Via Fantoli 16/15, Milan, Italy.

Job description

Very old patients with cardiovascular diseases (CVD) have higher mortality and risk for disability after hospitalizations. This increased vulnerability is termed frailty and it is frequent in older patients with CVD. Frailty, defined as an increased vulnerability to stressors by a decrease in physiological reserves of multiple body systems, is an independent predictor of autonomy loss and poor prognosis including death. Few studies tried to systematically dissect the existence of molecular biomarkers able to predict frailty progression. In particular, the ability of miRNAs and inflammatory proteins to identify frailty and predict its progression or response to interventions is poorly studied. Two goals of the project are: 1) a panel of molecular biomarkers can identify frailty, predict its progression and response to interventions; 2) selected molecules clinically associated with frailty play a role in the pathways held to drive aging.

Responsibility

Employer

IRCCS MultiMedica is a center of excellence for cardiovascular research and offers a highly stimulating scientific environment that supports the close interactions between basic researchers, translational researchers, and clinicians. The Institute is equipped with advanced instrumentations for biomedical research.

Profile requested

Acquired skills in the following procedures are highly encouraged:
Plasma preparation from blood samples

RNA extraction from plasma and cells

Confidence with miRNA Profiling with Microarrays or comparable technique

RT-PCR

Cell culture

Transient transfection or comparable technique

Western Blot

A strong attitude in working both independently and in collaboration with others is mandatory. Excellent communication skills in English are also necessary.

Education

Master’s degree in biology, biotechnology, pharmacy, or other closely related disciplines.

A PhD in molecular medicine or related fields is a plus but not mandatory.

Offer

An interesting and varied job in a stimulating environment with the opportunity to contribute with innovative ideas.

Working in a highly motivated and dynamic team with flat hierarchies.

**Publications from the groups involved in the project (link)**: