Senior Medicinal Chemist in Translational Research

2 giorni fa


Genoa, Liguria, Italia Istituto Italiano di Tecnologia A tempo pieno

We are seeking an experienced Senior Medicinal Chemist to join our team at Istituto Italiano di Tecnologia in Genova, Italy. As a key member of our Computational and Chemical Biology Research Unit, you will play a vital role in the design, synthesis, and optimization of novel therapeutic compounds.

Job Overview

This is a senior-level position that requires extensive hands-on research experience in medicinal chemistry, particularly in the design, synthesis, and characterization of bioactive small molecules. You will be working collaboratively with multidisciplinary teams to identify biological targets and develop high-affinity molecules through structure-activity relationship (SAR) studies.

The successful candidate will utilize advanced medicinal chemistry techniques to enhance the potency, selectivity, and pharmacokinetic properties of hit and lead compounds. Additionally, you will participate in data analysis and interpretation to guide decision-making, ultimately supporting the transition of promising candidates into preclinical development.

About the Role
  • Design and synthesize novel compounds to support drug discovery, applying medicinal chemistry principles to optimize pharmacological properties and implementing innovative synthetic strategies for efficiency and scalability.
  • Perform SAR studies to refine hit and lead compounds. Utilize advanced analytical techniques, including HPLC, LC-MS, NMR, and other methods to characterize and purify compounds.
  • Work within cross-functional teams to integrate chemistry efforts, contributing to experiment planning and execution aligned with project goals.
Requirements

To be considered for this position, you must have a PhD degree in organic synthesis, synthetic medicinal chemistry, or pharmaceutical sciences. A minimum of 1-2 years of experience in medicinal and/or organic chemistry is required, as well as a proven track record of successful compound design, synthesis, and optimization.

You should possess technical skills in organic synthetic and purification techniques, as well as analytical methods, including NMR, MS, HPLC, and other relevant technologies. Excellent English communication skills, creativity, and enthusiasm for research are essential. Ability to work independently and collaboratively in a highly interdisciplinary environment is also required.

What We Offer
  • A competitive salary package for international standards.
  • Private health care coverage.
  • Wide range of staff discounts.

Istituto Italiano di Tecnologia offers a dynamic and inclusive work environment where diversity and innovation thrive. If you are passionate about medicinal chemistry and eager to contribute to cutting-edge research, we encourage you to apply.



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