Postdoc in Molecular Systems Biology

APPLICATION CLOSING DATE: November 30th, 2025Human Technopole (HT) is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of six Centers: Neurogenomics, Computational Biology, Structural Biology, Genomics, Molecular Cell Biology and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.About The Flagship Research ProgrammeFlagship Research Programmes at HT are strategic collaborative efforts that leverage the cutting-edge expertise and infrastructure available at HT for translational research focused on different human pathologies.About The LabThe Legnini Group at Human Technopole ( ) combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and optogenetics to engineer cells and organoids with the aim of reproducing complex regulatory cascades, then apply integrative transcriptomic readouts to understand the principles of gene regulation, particularly in neurodevelopment. At the same time, we use and develop high-throughput transcriptomic technologies and quantitative models of RNA metabolism to study mRNA regulation from synthesis to degradation.See previous work on the lab’s research topics About The PositionWe are seeking a highly motivated postdoc to study how genetic and environmental risk factors interact in the context of neural tube defects. The candidate will use stem-cell derived organoid models, genetic engineering, single-cell transcriptomics and imaging readouts to understand the mechanisms underlying specific congenital defects of neural tube morphogenesis.Key Tasks And ResponsibilitiesConduct research and develop innovative methods to achieve project goals. Generate, document, and analyze high-quality experimental data for publications and grants. Contribute to scientific dissemination through papers and conference presentations. Mentor students and junior staff, providing internal training and technical guidance. Collaborate with internal teams and external experts to share knowledge and support project development. Design and manage research plans and experiments in coordination with Group Leaders and colleagues. Job RequirementsEssential requirementsHold a PhD in a life science discipline by the time of application or the position starting date. Consolidated experience in mammalian cell culture, imaging and molecular biology techniques. Preferred RequirementsPrevious experience with human stem-cell derived models, especially organoids. Good knowledge of developmental biology and/or neurobiology. Good knowledge and/or previous experience with RNA sequencing techniques, including single-cell RNA sequencing. Organisa tional and social skillsMentoring capabilities. Strong technical expertise in facility operations and IT integration. Excellent organizational and strategic planning skills. Outstanding communication and networking abilities. Application InstructionsTo Apply, Please Send The Followinga CV. a motivation letter in English relating your track record to the specifics of the call. names and contacts of 2 referees. Why Human TechnopoleHT seeks scientific excellence, we recruit the best scientific talents through international, open calls.Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.We believe that highly diverse teams yield the best and most innovative results.We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.Main BenefitsWelfare plans. Meal delivery service. Work-life balance provisions. Italian language training for non-native speakers. Parental leave up to 1 year and other support for new parents. Flexible working hours. Remote working policy. Support for relocation. Researchers coming to Italy for the first time, or returning after residing abroad, benefit from very attractive income tax benefits. Special consideration will be given to candidates who are part of the protected categories list, according to L. 68 ⁄99 .Number of positions offered: 1Contract offered: CCNL Chimico Farmaceutico, Fixed-term 4 years with possibility of renewal - CCNL Level: B2Tax benefits where applicable.The position is based in Milan.The Foundation reserves the right, at its sole discretion, to extend, suspend, modify, revoke, or cancel this job posting without giving rise to any rights or claims whatsoever in favor of the candidates; the Foundation reserves, however, the right not to proceed with the awarding of the above-described assignment due to the effect of supervening regulatory provisions and/or obstructive circumstances.