Principal Statistician

Additional Job Description
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
Find out more:
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.
Find out more:
Our approach to R&D
Job title: Principal Statistician
Location: Siena, Italy
Employment type: Permanent, Full-Time
Closing date for applications: 23 August 2026
Scope
Provide stat expertise to support the different study designs.
Responsibilities
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
Use stat methodology to establish study strategy (e.g.power modelling of different scenarios, set up power monitoring, set up mitigation plan to minimize risk of stat failure)
Provide input to protocol (design, objective, endpoint, randomization strategy, sample size, stat analysis)
Provide input to study set up (CRF review, randomization, DMP plan including specification for subset, important protocol deviation)
Lead or contribute to Quantitative Decision Making activities, including development of Probability of Success assessments, simulation-based evaluations, scenario analyses and other quantitative approaches that support project, governance and portfolio decisions
Develop SAP/AAR (involving sensitivity analysis to support robustness of result) and coordinate review
Review the TFL, to coordinate review with the stat analyst, to approve the TFL
Do the QC of the statistical analysis methodology
Validate study specific dataset & analysis pgm specification
Approve deviation from TFL format
Propose SAR conclusion
Prepare answer to study specific stat question (e.g. inspection, RA question)
Provide stat support to an independent analysis center
Provide consultancy on stat matter for other statisticians
Why you?
Basic Qualifications & Skills
Master Degree in Statistics, Mathematics, Epidemiology or equivalent, with at least 5-year experience in the pharmaceutical industry; OR PhD in Statistics, Mathematics or Epidemiology or equivalent with at least 2-year experience in the pharmaceutical industry.
Experience in Statistical software (R preferred) and sample size computation for standard designs.
Ability to work in multidisciplinary team (e.g. give guidance to non-stat, provide feedback, engage), some being remotely located.
Good oral and written communication in English including ability to explain difficult issues and situations clearly and ensures meaning is understood.
Fluent level of English, both written and spoken. Italian language skills are preferred
Preferred Qualifications & Skills
Has been previously responsible for studies with different designs (dose range, superiority/non inferiority, futility rule,..)
Strong communication skills, with the ability to explain complex statistical topics clearly
Ability to collaborate effectively in cross‑functional teams
Problem‑solving mindset and ability to handle complex situations
Leadership and influencing skills, including the ability to guide and mentor others
Attention to detail and strong quality focus
Adaptability in a fast‑paced, multicultural environment
What we offer
Permanent contract in a very Inclusive environment
Smart Working up to 50% for eligible roles
Flexible Benefits
Company Healthcare Plan
Integrative pension fund
Employee Assistance Programme
Prevention services and vaccination clinic
Tax assistance
Local nursery agreement
Postal service, laundry, shoe repair and tailoring
On Site Gym
On Site canteens and coffee corners
Free company bikes and shuttle
Skills
Central Monitoring, Clinical Data Management, Clinical Development, Cross-Functional Teamwork, Data Acquisition (D