Molecular mechanisms of nephroprotection by SGLT2 inhibitors: interaction between SIRT1 and hypoxia

Organisation/Company Sapienza Università di Roma Research Field Medical sciences » Medicine Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 7 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description This project aims to investigate the molecular mechanisms underlying the nephroprotective effects of SGLT2 inhibition, with a focus on the role of the SIRT1/HIF-1α/HIF-2α signaling axis in diabetic nephropathy. The study will explore how empagliflozin (EMPA) modulates the balance between HIF-1α and HIF-2α through SIRT1 activation and how these pathways influence cellular adaptation to metabolic and hypoxic stress.
Italy
Eligibility of fellows: country/ies of residence:
EUROPE
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