Post-doctoral Research Scientist

2026/01 | Milan

IFOM is an internationally recognized non-profit cancer research institute supported by the Italian Association for Cancer Research (AIRC) based in Milan within a highly dynamic urban environment.

IFOM's continuous success is ensured by the recruitment of highly-competitive undergraduate, graduate and post-graduate researchers worldwide, with over 24 countries currently represented in IFOM.

IFOM labs are hosted within a research campus shared with the European Institute of Oncology and the Italian Institute of Technology.

IFOM is committed to creating a safe and inclusive work environment, based on mutual respect and on the enhancement of diversity, offering equal job opportunities to all qualified candidates.

We seek for our Institute: Post-doctoral Research Scientist | Buffa's laboratory

The Buffa Lab is seeking a highly motivated postdoctoral scientist to work on a project entitled "Single-cell AI-reconstructed gene network rewiring in hypoxia to dissect mechanisms of cancer progression and metastasis (REWIRE)".

The laboratory uses systems biology approaches to understand how cancer evolves and responds to treatment, and how the tumor microenvironment affects this process. In our previous studies, we have extensively characterized the transcriptional response to hypoxia, in bulk and single cells, in multiple cancer types.

This project aims to further understand the reprogramming of cells exposed to early and chronic hypoxia in multiple experimental models, with a particular focus on CRISPR and single cell sequencing. The project will involve perturbation experiments in cell lines, organoids and single cell next generation sequencing approaches.

Department overview:

The ideal candidate will possess robust communication skills, self-motivation, and the ability to work autonomously. Additionally, they should be capable of fostering collaboration and constructive contributions within IFOM's scientific environment.

• Proficiency in advanced biochemical, molecular and cell biology techniques
• Demonstrable knowledge and experience of current omics and CRISPR assays
• Publications in internationally recognized journals
• Presentations at conferences, seminars or other relevant meetings
• Ability to work independently and as part of a team
• Ability to lead and manage small research projects
• Attention to detail and accurate data management
• Reliability and flexibility

Proficiency in English for speaking and writing. English is the working language at the Institute.

• PhD or equivalent degree in Molecular Biology, Genetics, Biotechnology or related field
• Research experience in genomics, functional genomics and perturbation-based assays
• Advanced molecular biology techniques
• Experience with CRISPR-based screens
• Experience with transcriptomics, single-cell genomics or proteomics
• Proven publication record in peer-reviewed journals
• Excellent communication skills

• First-author publications in internationally recognised journals
• Previous grant funding
• Experience with other biochemical techniques (e.g. shRNA)

PhD in molecular or cellular biology or a related field.

• International work environment
• Flextime
• Discount agreements (gym, pharmacy, psychology services, local shops)
• Bar and canteen on campus with lunch benefit
• Company nursery
• Relocation and family support via Welcome Office
• Medical service
• Laptop
• CAF service for tax declaration

Annual renewable fellowship (post-doc) or contract. A competitive salary will be offered, commensurate with skills and experience.

Milan – Scalo di Porta Romana area

Interested candidates should send a motivation letter, CV and contact information for at least two references to:

This announcement is addressed to both sexes pursuant to Laws 903/77 and 125/91 and to people of all ages and nationalities pursuant to Legislative Decrees 215/03 and 216/03.

last update: 22/01/26