Identification Of Novel Cardiokines Regulating Systemic Diurnal Metabolism In Heart Failure

26 minuti fa


Lazio, Italia Humanitas University A tempo pieno

Humanitas University – Biology Researcher – Application Deadline 25 Feb *********:00 (UTC)OverviewThe project aims at defining the secretome of a healthy and diseased heart and to investigate how these secreted molecules impact systemic circadian metabolism in heart failure.To this end, we will employ a cardiomyocyte-specific, in vivo labeling approach, allowing for the labeling, enrichment, and identification of proteins secreted by the heart during pathological cardiac hypertrophy.The identified cardiomyocyte-secreted factors will be functionally screened in vitro and then in vivo via AAV9 mediated cardiac-specific overexpression of selected candidates, followed by metabolic phenotyping.LocationItalyEligibility of fellows – Country of residenceEUROPEEligibility of fellows – NationalityEUROPE#J-*****-Ljbffr



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