Dissecting The Role Of Calcium On Collagen Secretion In Osteogenesis Imperfecta

12 ore fa

Lazio, Italia Università Di Pavia A tempo pieno

Organisation/Company Università di Pavia Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 26 Feb *********:00 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme?Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?NoOffer DescriptionCollagen type I is the most abundant structural protein in the human body and its synthesis and secretion require tightly regulated endoplasmic reticulum (ER) function and intracellular calcium (Ca2+) homeostasis.Ca2+ is essential for collagen I folding, post- translational modification, ER stress signaling, and COPII-mediated export.The objective of this project is to investigate how alterations in ER and cytosolic Ca2+ concentration and dynamics affect collagen I trafficking and secretion.Using in vitro cellular models the study will (1) characterize ER and cytosolic Ca2+ levels and fluxes and (2) determine their impact onCOPII assembly and collagen I secretion.The public call with detailed attendance and selection rules (Art 4 and 6) can be found at: The selections are open to candidates, Italian or foreigner, in possession, on the date of the deadline for submitting applications for the admission to the selection, of a master's degree or single-cycle degree obtained no more than six years previously are eligible to participate in the selection process.These degrees must be relevant to the subject of the research activity.QualificationsExperience with molecular biology techniques (nucleic acid extraction, PCR, qPCR)Experience with biochemical and histological techniques on tissues and/or cells (protein extraction, preparation of histological samples, Western blotting, ELISA)Experience with cell culture techniques (stem cells and primary osteoblasts)Experience with handling of animal modelsCertification authorizing the handling of murine modelsEligibility of fellows: country/ies of residenceAFRICAEUROPEOCEANIANORTH AMERICASOUTH AMERICAASIAOTHEREligibility of fellows: nationality/iesAFRICAEUROPEOCEANIANORTH AMERICASOUTH AMERICAASIAOTHERSelection processThe application for admission to the selection procedure (dated and signed),the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: selecting the Competition Notice you have chosen.In order to register with the system, you must have an email address.Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format.The selection of candidates is carried out on the basis of qualifications and possible interview (with test of knowledge of the foreign language) (see Art. 1 par. 1 Call for applications).#J-*****-Ljbffr

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