Postdoctoral Position Endocytosis, Signalling and Cancer Lab
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Postdoctoral Position Endocytosis, Signalling and Cancer Lab IEO - European Institute of Oncology
Milan, Italy
€ 36.000 per year gross
About the Project: Breast cancer management is hindered by extensive molecular and phenotypic heterogeneity. Despite advances in molecular stratification and precision medicine, major unmet clinical needs persist, particularly in intermediate-risk Luminal breast cancer and triple-negative breast cancer (TNBC), the most aggressive subtype.
Our laboratory has recently developed two multigene signatures: PetSign, capturing metabolic (glycolytic) alterations, and StemPrintER, reflecting the acquisition of cancer stem cell properties.
This project aims to leverage these signatures to improve prognostic stratification of Luminal and TNBC patients and to identify FDA-approved drugs capable of targeting these phenotypes.
Role and Responsibilities: Derivation of a PetSign risk score (PRS) and a StemPrintER risk score (SPRS);
Benchmarking of PRS and SPRS vs. available BC predictors;
Molecular and phenotypic validation in BC lines of genes of PetSign and StemPrintER.
Qualifications: A PhD in Cancer Biology, Cell Biology, Molecular Biology, Systems Medicine or a related life sciences discipline;
Strong experience in mammalian cell culture and functional assays;
Experience in RNAseq, scRNAseq, and bioinformatics;
Familiarity with phenotypic heterogeneity and functional characterization of cancer cell states;
A genuine interest in translational cancer research.
Deadline 21 November
IEO - European Institute of Oncology
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milan, lombardy, Italia IEO - European Institute of Oncology Tempo pienoPostdoctoral Position Endocytosis, Signalling and Cancer Lab IEO - European Institute of OncologyMilan, Italy€ 36.000 per year grossAbout the Project: Breast cancer management is hindered by extensive molecular and phenotypic heterogeneity. Despite advances in molecular stratification and precision medicine, major unmet clinical needs persist,...
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Postdoc: Endocytosis, Signalling
3 giorni fa
Milan, Lombardy, Italia IEO - European Institute of Oncology Tempo pienoIEO - European Institute of Oncology in Milan, Italy invites applications for a Postdoctoral Position in the Endocytosis, Signalling and Cancer Lab. The project focuses on using PetSign and StemPrintER signatures to improve prognostic stratification in breast cancer and identify FDA-approved drugs targeting these phenotypes.Responsibilities include deriving...
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Postdoc: Endocytosis, Signalling
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milan, lombardy, Italia IEO - European Institute of Oncology Tempo pienoIEO - European Institute of Oncology in Milan, Italy invites applications for a Postdoctoral Position in the Endocytosis, Signalling and Cancer Lab. The project focuses on using PetSign and StemPrintER signatures to improve prognostic stratification in breast cancer and identify FDA-approved drugs targeting these phenotypes.Responsibilities include deriving...
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Milan, Lombardy, Italia IFOM The FIRC Institute of Molecular Oncology Foundation Tempo pienoPost-doctoral Research Scientist in Leuzzi’s LaboratoryIFOM The FIRC Institute of Molecular Oncology FoundationMilan, ItalyAbout the positionDesign and execute CRISPR-knockout (CRISPR-KO) and CRISPR-mediated base editing screens to investigate novel targets and biomarkers in cancer immunity;Perform experimental approaches to study DNA damage response (DDR)...
