Molecular Mechanisms Of Nephroprotection By Sglt2 Inhibitors: Interaction Between Sirt1 And Hypoxia Signaling In Diabetic Nephropathy

Organisation/Company Sapienza Università di Roma Research Field Medical sciences » Medicine Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 7 Nov ***:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
This project aims to investigate the molecular mechanisms underlying the nephroprotective effects of SGLT2 inhibition, with a focus on the role of the SIRT1/HIF-1?/HIF-2? signaling axis in diabetic nephropathy.
The study will explore how empagliflozin (EMPA) modulates the balance between HIF-1? and HIF-2? through SIRT1 activation and how these pathways influence cellular adaptation to metabolic and hypoxic stress.
Italy
Eligibility of fellows: country/ies of residence:
EUROPE
Eligibility of fellows: nationality/ies:
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