A Post doc position is available in the Grønbæk Group at Biotech Research and Innovation Centre

A Post doc position is available in the Grønbæk Group at Biotech Research and Innovation Centre (BRIC),

We are searching for a skilled and experienced post doc with specific interest in investigating early myeloid disease, clonal haematopoiesis, metabolism and obesity.

The focus of the Grønbæk group is Translational Haematology. The group is affiliated with Biotech Research and Innovation centre (BRIC), University of Copenhagen and Rigshospitalet (Central Copenhagen University Hospital).

Our overall aim is to understand the molecular mechanisms of haematological cancers and based on this; to design, develop and implement novel, scientifically based, clinical trials, with a strong focus on epigenetic therapies. This is done by bridging between clinical research at Rigshospitalet and the basic cancer biology research at BRIC, and in international collaborations with, among others, the Van Andel Research Institute, Michigan, USA and the Nordic MDS study group.

Our location at the Copenhagen Biocentre/BRIC provides optimal conditions for interaction with the basic scientists at BRIC. The group currently consists of 14 scientists, MD/scientists and students, one clinical research coordinator, 1 research nurse and 2 biomedical laboratory scientists.

The current position is part of a joint project ‘Deciphering the Mechanistic Links Between Obesity, Clonal Haematopoiesis and Myeloid Neoplasms’ together with Professor George Vassiliou, Cambridge Stem Cell Institute, University of Cambridge, United Kingdom funded by a ‘Molecular Mechanisms Linking Obesity and Cancer (MMLOC)’ grant from the Novo Nordisk foundation, which supports collaborative research projects with the purpose to reverse-translate clinical observations into mechanistic studies that will increaseour understanding of how obesity impacts carcinogenesis.

Obesity is a global health issue linked to increased risk of cancer, including blood cancers such as myeloid neoplasms (MN). Many MN arise from clonal haematopoiesis (CH)—the abnormal expansion of blood stem cell clones carrying somatic mutations. Haematopoietic stem cells interact with bone marrow adipose tissue (BMAT), which increases with obesity, which may fuel CH growth and progression to MN. Epidemiological and genetic studies already suggest obesity accelerates CH, but the underlying mechanisms remain unclear.

This project integrates large-scale population data, clinical trials, and mechanistic mouse studies to investigate these links and explore preventive or therapeutic strategies.

The project focuses on translational analyses of live frozen human cells from patient bone marrow (BM)/(BMAT) and blood samples from completed and ongoing clinical trials. We are searching for a skilled post doc who is very interactive and enjoys collaborations with other scientists – including younger scientists and clinician scientists.

• Process of live frozen patient material from clinical trials including isolation of defined cell populations, and quality control for downstream omics
• Perform in-house molecular techniques which may include Proteomics, PCR, ddPCR, and library/sample preparation for RNA-seq, ATAC-seq and DNA methylation analyses
• Coordinate genomic, transcriptomic, lipidomic, metabolomic analyses with our internal and external collaborating laboratories and take the lead on designing relevant sub-studies, integrating and interpreting the data
• Help establish the practical and regulatory framework for these collaborations, including material transfer and data-sharing agreements
• Participate in grant and manuscript writing
• Present at local and international meetings
• Introduce lab techniques to new lab members and students
• Collaborate with both scientists and clinicians

Start: February 1st, 2027

Duration: 2 years

• A PhD in Life Sciences with a preferred focus on haematology
• A strong background in mechanisms of normal and malignant haematopoiesis and molecular haematology techniques
• Comprehensive lab skills in molecular and cellular biology techniques, including work with primary human cells and cryopreserved patient material
• Experience with genomics, transcriptomics, proteomics, lipidomics, metabolomics and ability to analyse and interpret such data
• Experience with running projects across research groups
• Strong publication and presentation record in peer reviewed journals and international conferences
• Excellent written and spoken English skills
• Very collaborative
• Good social skills

The workplace is at the Bartholin Institute wh