Study of the interaction between the human Thymidylate Synthase and its mRNA through singlemolecule force spectroscopy experiments

Organisation/Company Università di Padova - Dipartimento di Fisica e Astronomia DFA Research Field Physics Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 18 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The researcher will be responsible for: synthesizing the molecules under investigation and optimizing their attachment to the surface of micrometer-sized polystyrene beads; using an optical tweezers instrument to optically manipulate individual RNA/protein molecules; realization of in-equilibrium and out-of-equilibrium force spectroscopy experiments; adjusting the physicochemical properties of the saline buffers used in the experiments; and analyzing experimental data using programs developed in MATLAB or Python

- for qualifications 20 points: degree, PhD, specialization diploma, certificates of attendance of post-graduate specialisation courses (obtained in Italy or abroad);
- for the scientific-professional curriculum 30 points: documented research activity carried out at public and private entities with contracts, scholarships or assignments (both in Italy and abroad) relevant to the research activity subject of the announcement;
- for scientific productivity 10 points: quantity and quality of scientific publications, including master's or single-cycle master's or doctoral theses;
- for the interview 40 points.

• Italy

Eligibility of fellows: country/ies of residence:

• International

Eligibility of fellows: nationality/ies:

• International

Selection process

The selection is carried out through the comparative evaluation of qualifications, scientific-professional curriculum, scientific productivity by a Selection Committee appointed by the Director of the structure. The Selection Committee shall be composed of three effective members, including the Scientific Supervisor and/or the Tutor, and at least one substitute member.