Identification of post-transcriptional modifications of tumor suppressors in tumorigenic processes and their role in modulating the expression of immune checkpoints

Organisation/Company Università Sapienza Dipartimento di Medicina sperimentale Research Field Medical sciences » Medicine Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 6 Nov 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Colorectal carcinoma (CRC) frequently harbors mutations in tumor suppressor genes—including *TP53*—that are associated with tumor progression and treatment resistance. Mutant p53 (mutp53) has been shown to sustain HDAC6 expression, thereby promoting DNA damage repair and resistance to endoplasmic reticulum (ER) stress via ATF6. Preliminary data suggest that ATF6 increases TRAPPC4 expression, promoting the trafficking of PD-L1 to the cell membrane. Furthermore, HDAC6 deacetylates MSH2 and promotes its degradation, thereby impairing mismatch repair and contributing to mutation accumulation, neoantigen production, and immune checkpoint expression. This project aims to characterize the epigenetic alterations induced by mutp53 and their contribution to therapeutic resistance and tumor immunogenicity

• Italy

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• OTHER

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