Insights into the mechanisms of alternative macrophage polarization to overcome resistance to cancer immunotherapy

9 ore fa
italy Italian Ministry of Education, University and Research Tempo pieno

Organisation/Company Università degli Studi di Napoli Federico II Research Field Chemistry » Biochemistry Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 20 Oct 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The project investigates the role of the FKBP51s splice isoform in tumor-associated macrophages (TAMs) and immunosuppression, aiming to overcome resistance to immunotherapy in melanoma. Research activities will explore the contribution of FKBP51s to macrophage polarization and its potential as a therapeutic target for metabolic reprogramming, through the evaluation of small molecules capable of modulating its activity. Functional assays will be performed using primary immune cells, syngeneic mouse melanoma models, and patient-derived organoids. The analysis of TAM surface markers, validated in patient blood samples and tumor-infiltrating immune cells, will aim to identify cellular signatures supporting patient selection and treatment response monitoring.

  • Italy

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  • EUROPE

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