Computational Discovery of Hemoglobin Modulators for SCD

Sapienza Università di Roma seeks a research fellow to advance a project on developing a computational model for selecting novel hemoglobin allosteric modulators. The work includes virtual binding studies targeting the allosteric site, evaluating selected compounds for hemoglobin inhibitory activity, and refining leads through virtual screening and chemical synthesis.
Selected candidates will assess activity on hemoglobin and test lead compounds on erythrocytes from patients with sickle cell