Bioinformatician in Functional Transcriptomics

1 settimana fa

Milano, Lombardia, Italia Human Technopole A tempo pieno



APPLICATION CLOSING DATE:
5th September 2023

Human Technopole (HT) is a new interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health.

HT is composed of five Centers:
Computational Biology, Structural Biology, Genomics, Neurogenomics and Health Data Science.

The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally.


Human Technopole is looking for a
Bioinformatician in Functional Transcriptomics, to be appointed in the Genomics Research Centre under the supervision of the Group Leader Dr.

Lorenzo Calviello.

About the lab:


The Calviello Lab is a hybrid computational/experimental research group interested in post-transcriptional gene regulation at -omics scale, with a focus on translation and its many connections to mRNA and proteome dynamics (if you are curious discover more here: Integrative -omics in mRNA biology ).


See previous work on the research topics of this call:
Calviello et al, Nature Methods 2015

Calviello & Ohler, Trends in Genetics 2017

Calviello et al, Nucleic Acid Research 2021


On campus, an advanced training program on research and transferable skills provides plenty of opportunities for personal and professional growth.


Key tasks and responsibilities:

  • Develop machine learning models for the highresolution analysis of different transcriptomics datasets.
  • Perform _in silico _experiments to stress model capabilities in capturing relevant signals under different perturbations.
  • Write wellannotated, reproducible code with clear visualizations, employing essential tools in computational research, such as version control and dynamic reporting (e.g. git, Jupyter notebooks, Rmarkdown).

Mandatory requirements:

  • Master's degree in Computational Biology or related discipline, with a focus on quantitative analysis methods.
  • Proven track record of research in Computational Biology, Functional Genomics and/or Machine Learning.
  • Background in statistical learning methods, with a focus on interpretable models.
  • Strong programming skills in R (Bioconductor) and Python.

Preferential requirements:

  • Robust knowledge of mRNA biology.
  • Strong knowledge of next generation library preparation techniques.
  • Previous experience with analysis of multiple RNAseq technologies.
  • Experience in developing documented computational tools for omics data.
  • Familiarity with time series analysis and AI approaches (e.g. Natural Language Processing).
  • Phd in Computational Biology or related discipline, with a focus on quantitative analysis methods.

Desired personal skills:

  • Ability to work independently.
  • Willingness to frequently and openly discuss results and ideas, highlighting controls and potential pitfalls, using concise and clear presentations.
  • Fluency in English (HT is an international research institute).
  • Motivation to interact lively with colleagues in the lab, other departments, and the larger scientific community in various events (journal clubs, lab meetings, seminars, hackathons, international conferences, etc.).
  • Strong communication skills and respect for their own and other colleagues' work, towards fostering a transparent, collaborative, stimulating, and welcoming scientific environment.

Application instructions:

- a CV
- a motivation letter in English
- the name and contact details of at least 3 potential referees.

Why Human Technopole

  • HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.
  • Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches.
  • We believe that highly diverse teams yield the best and most innovative results.
  • We engage in outwardfacing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.

Main benefits

  • Welfare plans.
  • Canteen service.
  • Worklife balance provisions.
  • Italian language training for foreigners.
  • Parental leave up to 1 year and other support for new parents.
  • Counseling.
  • Flexible working hours.
  • Remote working policy.
  • Support for relocation.
  • Researchers coming to Italy for the first time, or returning after residing abroad, could be eligible for very attractive income tax benefits.
Number of positions offered: 1.

Contract offered:
CCNL Chimico Farmaceutico, Fixed-term 5 years - employee level.

The position is based in Milan.

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