Postdoctoral Position
3 giorni fa
IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a Postdoctoral research fellow position to join the Unit of Gene and Neural Stem Cell Therapy for Lysosomal Storage Diseases.
The translational project will focus on precise genetic modifications in glia cells to silence/correct disease-causing mutations in Alexander disease, an autosomal dominant neurodegenerative disorder.
We already optimized novel CRISPR/Cas9-based approaches.
In the project, the Postdoc will provide in vitro and in vivo proof-of-concept of efficacy and safety of these editing platforms in murine and human disease models.
**Main activities**:
development of AAV and LV platforms to target astrocytes;
development of nanoparticle-based delivery systems (in collaboration with national and international teams);
in vitro and in vivo proof-of-concept studies in murine disease models;
in vitro gene editing analyses and disease modeling studies in human hiPSC-based models;
advanced NGS and bioinformatic analysis.
**Who we are looking for**:
PhD in Neuroscience, Cellular and Molecular Biology or related areas;
Solid knowledge of Neuroscience, and an expertise in advanced molecular biology techniques (CRISPR systems) and/or in vivo gene therapy in murine models;
Significant track record of accomplishments;
High level of independence;
Excellent analytical, organizational and communication skills in spoken and written English;
Ability to work independently as well as with interdisciplinary teams.
**Work details**:
**Type of contract**: fixed-term contract with Competitive salary depending on qualifications and experience
**Duration**: one year, renewable up to three years;
**Place of work**: San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.
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