Bioinformatician/sr. Bioinformatician, Functional

2 mesi fa

Milano, Italia Human Technopole A tempo pieno

**APPLICATION CLOSING DATE: April 17th, 2023.**

**Human Technopole (HT)** is looking for a **Bioinformatician **for** the** **Functional Genomics Computation Unit **in the** Centre for Genomics - F**unctional Programme.**

HT is a new interdisciplinary research institute, created and supported by the Italian government, whose aim is to develop innovative strategies to promote human health and aging through a multidisciplinary and integrated approach, combining genomics, computational and structural biology and neuroscience, as well as data and decisions sciences.

The mission of the Centre for Genomics - Functional Programme will be to elucidate key biological questions including “how the genome is regulated in each cell, tissue and organ in health and disease”, “what are the molecules and networks that drive biological activity in cells, tissues, organs”, and “how to modify genome regulation and genome output in health and diseases”. We will identify and characterize functional and regulatory non-coding genomic element networks in different cells and tissues of the human body, with the goal to identify the grammar of the genome, which will ultimately provide deeper understanding of genome function and enable biology and genomics medicine.
To address these challenges, the Centre develops original technologies to identify and functionally characterize regulatory elements, long non-coding RNA, genome conformation, interactomes of biological molecules in living cells and computational approaches to study genome regulation. These approaches will be broadly used to map the function and regulation of human genome in health and diseases across human diversity and ultimately derive actionable targets.

We are looking for a Bioinformatician in the **Functional Genomics Computation Unit**, a new state-of-the-art unit for the analysis of large volumes functional genomics deriving from a variety of technologies and approaches. This unit will support the data analysis efforts of the research groups in the Functional Genomics Programme. The Unit will rely on data generated by the research teams and units in the Centre and the High Throughput Genomics Core Facility of HT. The unit will also be involved in the analysis of data generated by external collaborators and publicly available data when required. The Unit will benefit from a large High-Performance Computing and Data Storage infrastructure, and from close interaction with an expert community of computational biologists within the Genomics Centre, other Research Centres, and of core facilities at HT.

The post will be responsible for setting up and running state-of-the-art computational workflows for functional genomics and will be involved in functional analysis of key datasets. A key mission will be to ensure the processing and delivery of analysed data for large-scale projects, including through bespoke collaborations with Investigators of the Research Programme and other Research Centres. They will also be expected to contribute to the development of new methods and the rapid standardization/implementation of new computational approaches for emerging technologies. Reproducibility and robustness of bioinformatics analyses, using standardised and modular workflows, will be at the core of this role.

**Key tasks and responsibilities**
- Setting up and operating bioinformatics analysis pipelines to process transcriptomics and functional genomics data, using short
- and long-read technologies, including but not limited to genomics analysis from bulk, single cell genomics and multiomics datasets.
- Design, set up and maintain data analysis pipelines and software for genomics analysis downstream of the pipelines (eg identification of promoters, enhancers, regulatory elements; interactomes; annotation of transcripts and promoter, termination and splicing variants, RNA modifications etc.).
- Manage import, storage and use of external datasets (eg: ENCODE, Human Cell Atlas, FANTOM), including control of appropriate access rights and data annotation.
- Manage storage and maintenance of genetic and genomic datasets produced by the research groups, curation of data for depositions in public repositories. Data harmonization of genomic resources; curation of metadata of experiments
- Processing and analysis of datasets for faculty groups or for cross-centre and external collaborative projects.
- Curation of functional genomics elements, from projects of the Center, the broader HT and broader collaborations.
- Provide support, training and supervision to member of the department (students and staff) on scientific computing and functional genomics tools and analyses
- Participate in preparing accessible resources/databases for the community-wide fruition of the data generated within the research programs;
- Support development of accessible resources for the community-wide fruition of the data generated within the research program, including liaising with the major e

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