Mrna Formulation Scientist

1 settimana fa

Monza, Italia Thermo Fisher Scientific A tempo pieno

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.

The Scientist will join the mRNA Process & Analytical Method Development Group and will contribute to the process & analytical methods development, improvements, and transfer of mRNA products to GMP and QC groups. Key responsibilities will include hands-on laboratory mRNA process characterization & development, process improvements, development in the context of mRNA-lipid nanoparticle (LNP) drug products, and technical document drafting.
- Responsibilities:
- Design, develop, and implement workflows for high-throughput mRNA production.
- Use a data-driven approach to progress development deliverables.
- Process development, improvement, and troubleshooting for LNP/mRNA production at various scales.
- Characterize LNP formulations and components using: Dynamic Light Scattering (DLS), Ribogreen, and high-performance liquid chromatography (HPLC).
- Develop novel assays or in-depth studies of specific LNP attributes as required.
- Screen final formulation buffers and excipients to increase the long-term stability of LNPs.
- Characterize and evaluate LNP formulations to support internal and customer programs.
- Conduct troubleshooting process performance issues.
- Support scale-up of upstream/downstream processes and technology transfer to the cGMP manufacturing and quality control (QC) groups for clinical material production/analysis.
- Perform routine bench work under limited supervision, effectively prioritize responsibilities and complete assignments on time.
- Discuss internally and with customers the progress of the activities proposing technical solutions.
- Ability to analyze, interpret, and present results to project teams and write technical reports.
- Maintaining domain expertise in new technologies and scientific literature to constantly drive innovation.
- Train junior scientists as needed.
- Qualifications:
- Requirements:
- Experience in manufacturing LNPs using Microfluidics, T-mixer, or other inline mixers.
- Experience with tangential flow filtration (TFF) and sterile filtration.
- Proficiency with related LNP/mRNA analytical techniques: plate-based fluorescence assays, high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC/MS), capillary gel electrophoresis (CGE), Dynamic Light Scattering (DLS), zeta potential. There may be additional techniques (PCR, qPCR, UV-Vis spectrophotometry).
- Direct experience in the production and analytical characterization of mRNA lipid nanoparticles as well as the characterization and handling of mRNA products.
- It would be advantageous to have specific experience with the process development of mRNA lipid nanoparticle products.
- Excellent understanding of the mRNA delivery scientific literature.
- Knowledge of design of experiments (DoE) statistical techniques, process modelling, and bioprocess engineering principles.
- Experience with tech transfer to GMP manufacturing preferred.
- Experience writing content for documentation, including SOPs, work instructions, technical protocols and reports, and technical presentations.
- A high level of commitment and a track record of quality work, with attention to detail.
- Capable of communicating the work clearly among the team.
- Ability to multi-task and prioritize to meet important deadlines.
- Ability to respond quickly to rapidly changing priorities.
- A self-starter and standout colleague.
- Excellent written and spoken English.

Thermo Fisher Scientific is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, creed, religion, colour, national or ethnic origin, citizenship, sex, sexual orientation, gender identity and expression, genetic information, veteran status, age or disability status.

Join us

  • Mrna Formulation Scientist

    3 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories,...

  • Mrna Scientist

    3 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing productivity in their laboratories, improving...

  • Mrna Scientist

    7 giorni fa

    Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing productivity in their laboratories, improving...

  • Pds Formulation Scientist

    2 mesi fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    **What you will do** As a part of our Formulation - Pharmaceutical Development team you will be supporting the manager in ensuring process development activities for batches destined for clinical trials and for commercial manufacturing. In addition, you will ensure the scale up/ technology transfer and processes of new sterile products into Pharmaceutical...

  • Mrna Scientist

    3 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories,...

  • Mrna Scientist

    7 giorni fa

    Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories,...

  • PDS Senior Formulation Scientist

    4 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their laboratories, improving...

  • PDS Senior Formulation Scientist

    3 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their laboratories, improving...

  • PDS Senior Formulation Scientist

    3 settimane fa

    Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

    Job DescriptionThermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their...

  • PDS Senior Formulation Scientist

    1 mese fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Job DescriptionThermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their...

  • PDS Senior Formulation Scientist

    3 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Job DescriptionThermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their...

  • PDS Senior Formulation Scientist

    4 settimane fa

    Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

    Job DescriptionThermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their...

  • PDS Senior Formulation Scientist

    4 settimane fa

    Monza, Lombardia, Italia ThermoFisher Scientific A tempo pieno

    Job DescriptionThermo Fisher Scientific Inc. is a global leader in the field of scientific services, with an annual revenue exceeding $40 billion. Our mission is to empower our clients to enhance the overall well-being of the world by fostering a healthier, cleaner, and safer environment. Whether our clients are accelerating research in life sciences,...

  • PDS Senior Formulation Scientist

    3 settimane fa

    Monza, Lombardia, Italia ThermoFisher Scientific A tempo pieno

    Job DescriptionThermo Fisher Scientific Inc. is a global leader in the field of scientific services, with an annual revenue exceeding $40 billion. Our mission is to empower our clients to enhance the overall well-being of the world by fostering a healthier, cleaner, and safer environment. Whether our clients are accelerating research in life sciences,...

  • Manufacturing Specialist, Mrna Manufacturing

    4 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing productivity in their laboratories, improving patient...

  • Manufacturing Specialist, Mrna Manufacturing

    3 settimane fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing productivity in their laboratories, improving patient...

  • Scientist Support Intern

    2 mesi fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    The Scientist Support Intern has the task of supporting the figure of the Scientist in the management of activities necessary for the execution of projects intended for the production of sterile pharmaceutical products. In particular, the SSI will have the task of supporting the Scientist in the daily activities of selecting and managing materials for...

  • Pds Analytical Scientist

    5 giorni fa

    Monza, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their laboratories, improving...

  • Pds Analytical Scientist

    7 giorni fa

    Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

    Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of more than $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, growing efficiency in their laboratories, improving...

  • Scientist I, Process and Analytical Development

    2 mesi fa

    Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

    Job DescriptionWe are seeking two highly motivated candidates for the role of Junior Scientists in the mRNA Process, Analytical and LNP Formulation Development team in Monza (Italy). The candidates shall have strong ability in upstream/downstream process development and are expected to work in a fast-paced environment with high self-motivation. The Junior...