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Research Associate in Computational Biology
2 mesi fa
Project Overview:
Contract Type: Collaboration agreement
Location: Genova
ABOUT THE INSTITUTION
At the Istituto Italiano di Tecnologia, we are dedicated to advancing human-centered Science and Technology to address critical societal challenges and to facilitate the transfer of these innovations to the production sector and society at large. Our headquarters in Genoa are closely linked with 11 other centers across Italy and two outstations in the United States. We are committed to excellence in both fundamental and applied research, fostering a truly multidisciplinary scientific environment.
YOUR RESEARCH TEAM
You will collaborate within a diverse team where computational scientists and molecular biologists combine their expertise to pursue a unified research objective. Our goal is to elucidate how non-coding elements (DNA/RNA) and their epigenetic modifications influence 3D genome structure and gene expression in stem cell and cancer models. To tackle this challenge, we employ advanced chromatin conformation techniques such as Hi-C, Hi-ChIP, and Pore-C, alongside various -omics methodologies (e.g., ChIP-seq, TT-seq, scRNA-seq) and CRISPR-based genetic and epigenetic engineering tools. Data generated in-house will be integrated with publicly available datasets to investigate how non-coding RNAs can establish and sustain 3D promoter-enhancer interactions, ultimately shaping the transcriptional programs that govern stemness and tumorigenesis.
As a participant in the FANTOM6 project, postdoctoral researchers in our laboratory will have the chance to engage in consortium meetings and explore collaborative opportunities within IIT and with external institutions to develop new methodologies.
KEY RESPONSIBILITIES:
- Analyze next-generation sequencing data and integrate multi-omics datasets generated through various techniques using computational tools and workflows.
- Interpret findings and create visual representations for grant applications and publications in peer-reviewed journals.
ESSENTIAL QUALIFICATIONS:
- PhD in Bioinformatics, Computational Biology, Computer Science, or a related discipline.
- Proficiency in programming languages such as R and Python, along with statistical methods applicable to biosciences.
- Demonstrated experience in analyzing next-generation sequencing data, including RNA-seq and ChIP-seq (prior experience with chromatin conformation data such as Hi-C is advantageous).
- Ability to work independently and think critically, with a proactive approach to teamwork and problem-solving.
- Strong publication history.
- Proficient in spoken and written English.
COMPENSATION AND BENEFITS:
- Competitive salary package aligned with international standards.
- Comprehensive private health insurance.
- Access to a wide range of employee discounts.
- International candidates or Italian citizens working abroad may qualify for significant tax deductions.
WHAT WE OFFER:
- An inclusive and diverse environment that welcomes all individuals. We have a strict no-discrimination policy.
- Opportunities for collaboration and networking within our labs.
- Support from a dedicated team to assist with administrative tasks, particularly during relocation.
- If you have entrepreneurial aspirations, you will find a community of skilled professionals eager to support your goals.
- A stimulating and innovative culture that encourages impactful work aimed at enhancing societal well-being.
- We uphold our core values of integrity, courage, social responsibility, and inclusivity, which guide our daily actions and our mission at IIT.
If you find this opportunity aligns with your career aspirations, we encourage you to consider applying.
