Technician in Multi-omics Technologies

**APPLICATION CLOSING DATE: June 10th, 2025**

The Human Technopole Foundation is looking for a **Technician in Multi-omics Technologies**for the IU2 **Multi-Omics Technologies** unit of the National Facility for Genomics.

The National Facility for Genomics provides state-of-the-art and innovative services in genomics. Its core mission is to implement robust experimental and analytical workflows to probe all major domains of genomic exploration, including but not limited to the analysis of DNA, RNA, chromatin and other markers of epigenetic and regulatory activity. These techniques can be applied to diverse areas of biology, with resolution spanning to whole organisms, to tissues or individual cells. Overall, NF Genomics aims to empower research in all domains of genomics for the Italian scientific community at large.

The NF for Genomics foresees four Infrastructural Units (IU):
**UI1 High Throughput Sequencing** mainly focused on providing state-of-the-art high-throughput sequencing services. This dedicated unit specializes in delivering top-tier genomics, transcriptomics, and epigenomics analyses, employing the latest protocols for sample processing and sequencing.

**UI2 Multi-Omics Technologies** specialized in multi-omics technologies. Its focus extends to providing cutting-edge services in single-cell and spatial multi-omics analysis, as well as long-read sequencing. This Unit closely collaborates with the Tissue Processing Unit and NF-Imaging, specifically dedicated to implementing spatial transcriptomics protocols.

**UI3 Technology Development** stays at the forefront of innovation, this dedicated team is committed to methods and technology development. The highly qualified staff is continuously engaged in the evaluation of new technologies and instruments, considering them for acquisition into our facility. We specialize in the optimization and scale-up of custom experimental protocols, offering these services to the broader scientific community.

**UI4 Computational Genomics** is the computational core of the NF Genomics, the team is dedicated to developing, implementing, and maintaining automated pipelines for the pre-processing and primary data analysis of sequencing data. This unit closely collaborates with the NF for Data Handling and Analysis.

**Key tasks and responsibilities**
- Perform sample and library preparation for various single-cell and spatial transcriptomics protocols, including automation-intensive workflows.
- Operate and manage proprietary software for single-cell and spatial transcriptomics platforms and software supporting data collection
- Use of NGS sequencers (i.e. Illumina, MGI, Oxford Nanopore platforms)
- Assist in developing and implementing standard operating procedures (SOPs) and experimental pipelines.
- Contribute to general facility management, including inventory control of samples, reagents, and equipment providing regular updates to colleagues and line manager

**Mandatory requirements**:

- Master’s degree in biology, genetics, biochemistry, or a related life sciences field.
- At least 1 year of hands-on experience with single-cell and/or spatial-omics technologies, including library preparation with 10x Genomics and/or Nanostring protocols.
- Knowledge of NGS sequencing platforms (i.e. Illumina, MGI )
- Practical experience with molecular biology techniques and laboratory protocols (e.g. digital electrophoresis, qPCR, quality controls checks).
- Background in histology and imaging techniques.
- Fluency in English (HT is an international research institute).

**Preferred requirements**:

- Experience with single-molecule sequencing technologies (e.g., Nanopore)
- Knowledge of bioinformatic tools for handling, storing, and preparing genomic data files.
- Previous experience in a core facility.

**Organizational and social skills**:

- Excellent attention to detail, strong organizational skills, and a proactive problem-solving mindset.
- Strong communication, teamwork, and problem-solving skills.
- Ability to independently develop, optimize, and implement research support within a collaborative team environment.
- Ability to interact effectively with colleagues, other teams’ members and work synergistically to drive projects forward.

**Application Instructions**

I) a CV

II) a motivation letter in English

III) names and contacts of 2 referees

**Why Human Technopole**
- HT seeks **scientific excellence**, we recruit the best scientific talents through international, open calls;
- Our working environment is **international**, **friendly** and **inclusive**. Our scientists **work together across disciplines** on research topics of biomedical relevance, **leveraging synergies** between their diverse skillsets and methodological approaches;
- We believe that **highly diverse teams yield the best and most innovative results;**
- We engage in **outward-facing scientific activities** aimed at benefiting the national and international **research community.**Traini