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6 giorni fa


Milano, Italia Ospedale San Raffaele A tempo pieno

IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a highly motivated Postdoctoral Fellow to join the Liver Gene Therapy Unit, SR-Tiget.The goal of our lab is to study liver dynamics during growth and homeostasis to devise permanent in vivo genetic engineering of hepatocytes for the treatment of metabolic diseases in pediatric patients.To this aim, we combine single-cell, organoids, and multiomic analyses, including the latest-generation spatial transcriptomics, together with advanced genetic engineering tools.The ERC-funded project builds on our recent findings that most hepatocytes are quiescent during liver growth, and only a fraction of them generate most of the adult tissue (Milani, Starinieri et al., J Hepatol We aim now to characterize molecular programs of mouse and human proliferating and quiescent hepatocyte subsets and assess their susceptibility to in vivo lentiviral gene delivery and targeted genome editing.Main activities:Characterization of molecular and functional heterogeneity of hepatocytes during liver growthIn vivo genetic modification of hepatocytesData analysis and critical interpretation of the resultsDiscussion of project results at internal and external meetingsTraining of younger fellows in the labWho we are looking for: the call is for a Post-doctoral fellow with the following requirements:Ph.D. in life sciencesProven track record of publications in recognized journalsDocumented experience in molecular and cellular biologyPrevious experience with mouse models or gene therapy is a plusWork details:Type of contract: renewable collaborationDuration: 2 yearsPlace of work: IRCCS San Raffaele Hospital, Via Olgettina, number 60 - Milan (Italy)At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success.We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognized status entitled to protection under applicable laws.We offer attractive conditions and rewards appropriate to an internationally competitive research organization.



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