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Junior Researcher On Mitochondria Targeting Approaches For Parkinson'S Disease
3 mesi fa
Institute for Biomedicine The Institute for Biomedicine, located at Bolzano's NOI Techpark, is a key component of Eurac Research, dedicated to improving health through precision prevention research.
This interdisciplinary effort seeks to predict, slow or preempt illness progression by understanding genetic, biological, environmental, and lifestyle factors.Utilizing a decade-long population study in collaboration with the South Tyrolean Healthcare Service, the institute offers access to extensive data and biological materials suitable for such research.
With a focus on neurological, cardiovascular, and metabolic health, the team employs state-of-the-art labs and innovative management to span the full translational research cycle, from data generation to potential clinical application.
In its focus area "Mitochondrial function and neuronal disease modelling" the Translational Genomics group is looking for a junior researcher to work on the available portfolio of mitochondrial targets for Parkinson's disease.
Specifically, the team is focused on genes and pathways of PD, in which disrupted mitochondrial function contributes to the pathological processes.
Using appropriate neuronal models that include iPSC-derived neurons grown in 2D and 3D culture, we are assessing molecular phenotypes and testing specific targets and pathways for interventional strategies.
We are offering a 1 year position for a scientist who has recently graduated (Master of Science) in Cell Biology, Neuroscience, Biology, Biotechnology or related disciplines.
Researchers with a recently obtained PhD are also invited to participate.Tasks:
The researcher will be involved in experimental work, data analyses and presentation, including the following tasks:
Cell line and iPSC culture and neuronal differentiationCloning techniquesBasic molecular and cell biology experiments (e.g. ddPCR, Western blot)Immunofluorescence and confocal microscopyFunctional assays (e.g. mitochondrial respiration, ATP synthesis, ROS signalling)Data analyses and statisticsPreparation of graphs, presentations, and data for manuscripts
Requirements:
MSc in Cell Biology, Neuroscience, Biology, Biotechnology or related disciplines (or recent PhD)Standard cell culture techniquesExperience in molecular and cell biology assaysPrevious experience with hiPSCs and/or hiPSC-derived neurons will be an advantagePrevious experience with confocal microscopy is an advantagePrevious experience in assessment of mitochondrial function is also an advantageExcellent written and spoken EnglishAvailability to start the job as soon as possibleWe offer:
The Institute for Biomedicine is offering a position for 1 year. The beginning of the contract will be discussed with the selected candidate. Salary will be proportional to experience.
How to apply:
Interested candidates should submit their application (CV, cover letter and further relevant documents) by
#J-18808-Ljbffr
