Postdoc Position in Detection and Quantification of

3 settimane fa

Milano, Italia Istituto Italiano di Tecnologia A tempo pieno

**Postdoc position in Detection and Quantification of RNAs and their modifications from nanopore direct RNA sequencing data**
- (2400003M)
- Commitment & contract:_ _collaboration contract_

**WHO WE ARE**

At IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society. Our Genoa headquarter is strictly inter-connected with our 11 centers around Italy and two outer-stations based in the US for a truly interdisciplinary experience.

**YOUR TEAM**

The **_GENOMIC SCIENCE_**_ _Research Unit is coordinated by Dr. Francesco Nicassio, who has extensive experience in **_Genomics_**_ _and _**_Non-Coding RNA biology_**_._ The lab is engaged in a number of projects in areas of cancer genomics, development and stem cells focusing on the role of noncoding RNA transcripts. Notably, our research activity is based on the integration of **Experimental models** with **Computational methodologies**, pointing out the reciprocal regulation of coding and non-coding RNAs.

Representative publications can be found here:

- RNA modifications detection by comparative Nanopore direct RNA sequencing - **Nat Commun.** 2021 doi.org/10.1038/s41467-021-27393-3
- Nanopore ReCappable sequencing maps SARS-CoV-2 5′ capping sites and provides new insights into the structure of sgRNAs - **Nucleic Acid Res**. 2022 doi.org/10.1093/nar/gkac144
- Benchmarking of computational methods for m6A profiling with Nanopore direct RNA sequencing - **Brief Bioinform.** 2024 doi: 10.1093/bib/bbae001 PMID: 38279646
- Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome - **Mol Ther Nucleic Acids. **2023 doi.org/10.1016/j.omtn.2023.102052 PMID: 38028201

Within the team, your **main responsibilities** will be:

- Developing new computational methods and analytical strategies to characterize the role of RNA modifications in a broad range of biological contexts, such as regulation of long non-coding RNAs, biogenesis and maturation of microRNAs and mechanisms of cancer progression and chemo-resistance;
- Coordinating and co-supervising junior members of the lab, participate to meetings and be involved in disseminating results from the Research Line Genomic Science headed by Dr. Francesco Nicassio.

**REQUIREMENTS**
- PhD level degree in a natural science discipline, such as Biology, Biotechnology, Mathematics, Physics, or similar
- Documented experience in genomics, bioinformatics and scientific programming in R or Python
- Good data analysis skills and a basic understanding of statistics
- Ability to properly report and organize data
- Good command in spoken and written English
- Team-working ability
- High motivation to learn
- Experience on Nanopore sequencing

**EXTRA AWESOME**
- Good level of knowledge on the biology of RNA modifications
- Experience with bioinformatics workflow management tools such as Nextflow or SnakemakeGood communication skills
- Strong problem solving attitude
- Spirit of innovation and creativity
- Ability to work in a challenging and international environment
- Ability to work independently and collaboratively in a highly interdisciplinary environment

**COMPENSATION & BENEFITS**
- Competitive salary package for international standards
- Private health care coverage
- Wide range of staff discounts

**WHAT’S IN FOR YOU?**
- A dynamic, lively, and international team of people, working together to bring research to a new level
- An equal, inclusive and multicultural environment ready to welcome you with open arms. Discrimination is a big NO for us
- We like contamination and encourage you to mingle and discover what other people are up to in our labs
- If paperwork is not your piece of cake, we got you There’s a specialized team working to help you with that, especially during your relocation
- If you are a startupper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations.
- If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society
- We stick to our values Integrity, courage, societal responsibility and inclusivity are the values we believe in They define us and our actions in our everyday life. They guide us to accomplish IIT mission

If you feel this tickles your appetite for change, do not hesitate and apply

**Application’s deadline: May 28**th** 2024***

Please note that this position is pending budget approval.
- We inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia._
- Your data will be processed by Istituto Italiano di Tecnologia, bas

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