mRNA and LNP Development Scientist

4 settimane fa


Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

Role Overview

We are seeking a dedicated professional to contribute to advanced projects in the field of mRNA and lipid nanoparticle (LNP) development. The successful candidate will be an integral part of cross-functional teams, engaging in complex problem-solving and knowledge-sharing activities.

Key Responsibilities

  • Engage in collaborative efforts within multi-disciplinary teams to tackle sophisticated challenges.
  • Formulate and execute experimental strategies, assess in-process data, and prepare comprehensive reports.
  • Establish and nurture robust relationships with clients through technical discussions.
  • Lead initiatives in the domain of mRNA and LNP technologies.
  • Identify and provide solutions for process-related risks and challenges.
  • Contribute to the enhancement of departmental workflows and the adoption of innovative technologies.
  • Exhibit adaptability to support various departmental activities.

Qualifications

A Master's Degree in Life Sciences, Chemical Engineering, Biological Engineering, or a related field, accompanied by over 5 years of relevant experience in the biopharmaceutical sector, ideally in a process development capacity. Alternatively, a PhD in Biochemistry, Chemistry, Chemical Engineering, Biological Engineering, or similar scientific disciplines, with a minimum of 2 years of pertinent post-doctoral or industry experience.

Essential Skills

  • Proficiency in biomolecule purification methods, including HPLC/FPLC chromatography (affinity, ion exchange, hydrophobic interactions, and size exclusion), tangential flow filtration (TFF), and other filtration techniques.
  • Familiarity with technology transfer processes and GMP manufacturing standards.
  • Experience in designing DoE studies and conducting high-throughput screening for purification methodologies.
  • Understanding of critical process parameters in in vitro transcription (IVT), reaction optimization, and scale-up processes.
  • Experience in the production of large mRNA constructs, including self-amplifying and circular RNA formats.
  • Knowledge of the mRNA-LNP encapsulation process, including scale-up and execution of relevant analytical techniques.
  • A proven ability to thrive in a dynamic and multifaceted work environment.

Thermo Fisher Scientific is committed to fostering an inclusive workplace.



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