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mRNA and LNP Development Scientist

2 mesi fa


Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno

Role Overview

As a key member of our team, you will engage in interdisciplinary collaboration on complex projects, spearheading problem-solving initiatives and conducting thorough lessons-learned reviews.

Key Responsibilities

  • Formulate and execute experimental strategies, interpret in-process data, and produce and evaluate comprehensive reports.
  • Establish and nurture robust client relationships through technical discussions and support.
  • Direct efforts in the domain of mRNA and LNP expertise.
  • Identify and provide solutions for process-related risks, challenges, and issues.
  • Contribute to the enhancement of departmental workflows and the adoption of cutting-edge technologies.
  • Exhibit adaptability to assist with various departmental activities.

Qualifications

A Master's Degree in life sciences, Chemical, Biological, or Process Engineering, or equivalent experience, with over 5 years of proven experience in the Biopharmaceutical sector, ideally in a Process Development capacity. Alternatively, a PhD in Biochemistry, Chemistry, Chemical Engineering, Biological Engineering, or related scientific disciplines, or equivalent experience, with a minimum of 2 years of relevant post-doctoral or industry experience.

Essential Requirements

  • Proficiency in biomolecule purification methodologies, including HPLC/FPLC chromatography (affinity, ion exchange, hydrophobic interactions, and size exclusion), tangential flow filtration (TFF), and additional filtration techniques.
  • Familiarity with technology transfer processes and GMP manufacturing standards.
  • Experience in implementing Design of Experiments (DoE) studies and high-throughput screening for purification workflows.
  • Knowledge of in vitro transcription (IVT) critical process parameters, reaction optimization, and scaling processes.
  • Experience in the production of large mRNA molecules, including self-amplifying and circular RNAs.
  • Understanding of the mRNA-LNP encapsulation process, including scale-up and execution of relevant analytical methods.
  • A proven ability to thrive in a dynamic and multifaceted work environment.

Thermo Fisher Scientific is an Equal Opportunity Employer.