Biological Systems Research Specialist
2 giorni fa
**About the Job**
Human Technopole, an interdisciplinary research institute in Milan (Italy), is seeking a highly motivated Biological Systems Research Specialist to join its team. As a key member of the Zerial Group, you will contribute to the understanding of cellular and tissue organisation across biological scales.
**Research Focus**
The Zerial Group investigates the molecular mechanisms governing cell and tissue structure using advanced microscopy techniques, cell biology, and computer-aided three-dimensional tissue reconstruction. The goal is to identify self-organisation rules underlying liver tissue structure and their implementation at the molecular level.
**Key Responsibilities**
- Conduct systematic spatiotemporal analyses of organelle markers in mouse liver tissues after partial hepatectomy using advanced microscopy methods.
- Develop geometrical models of the liver tissue and identify underlying molecular pathways responsible for hepatocyte polarity and tissue organisation.
- Perform RNAi-mediated gene silencing, lentivirus delivery, or genome editing using established protocols.
- Generate mutant lines with CRISPR/Cas technology.
- Characterise phenotypes and introduce genetic or pharmacological perturbations to re-engineer liver tissue structure and function.
**Requirements**
- Ph.D. in Cell and/or Developmental Biology.
- Experience in imaging (including advanced microscopy techniques and image analysis).
- Advanced cell culture techniques and isolation of primary cells.
- Expertise in gene editing, silencing, and overexpression techniques.
- Fluency in English language.
**Salary and Benefits**
The successful candidate can expect a competitive salary range of €60,000 - €80,000 per year, commensurate with experience. Human Technopole offers a dynamic and inclusive working environment with opportunities for professional growth and development.
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