Post-doctoral Research Scientist | Buffa's laboratory

IFOM is an internationally recognized non-profit cancer research institute supported by the Italian Association for Cancer Research (AIRC) based in Milan within a highly dynamic urban environment.IFOM’s continuous success is ensured by the recruitment of highly-competitive undergraduate, graduate and post-graduate researchers worldwide, with over 24 countries currently represented in IFOM.IFOM labs are hosted within a research campus shared with the European Institute of Oncology and the Italian Institute of Technology.IFOM is committed to creating a safe and inclusive work environment, based on mutual respect and on the enhancement of diversity, offering equal job opportunities to all qualified candidates.We seek for our Institute: Post-doctoral Research Scientist | Buffa's laboratoryThe Buffa Lab is seeking a highly motivated postdoctoral scientist to work on a project entitled “Single-cell AI-reconstructed gene network rewiring in hypoxia to dissect mechanisms of cancer progression and metastasis (REWIRE)”. The laboratory uses systems biology approaches to understand how cancer evolves and responds to treatment, and how the tumor microenvironment affects this process. In our previous studies, we have extensively characterized the transcriptional response to hypoxia, in bulk and single cells, in multiple cancer types. This project aims to take this further and understand the reprogramming of the cells exposed to early and chronic hypoxia in multiple experimental models, with a particular focus on CRISPR and single cell sequencing. The project will involve perturbation experiments in cell lines, organoids and single cell next generation sequencing approaches.Department overview: DescriptionThe ideal candidate will possess robust communication skills, self-motivation, and the ability to work autonomously. Additionally, they should be capable of fostering collaboration and constructive contributions within IFOM's scientific environment.Proficiency in advanced biochemical/molecular/cell biology techniques;Demonstrable knowledge and experience of current omics and CRISPR assays;Publications in internationally recognized journals;Presentations of scientific findings at conferences, seminars or other relevant meetings;Ability to work independently and as part of a team;Ability to take the lead and manage small research projects when required;Attention to detail and the ability to keep accurate and ordered experimental data;Reliability and flexibility;Language skillsProficiency in English for speaking and writing.English is the working language at the Institute.Required skillsPhD or equivalent degree in Molecular Biology, Genetics, Biotechnology, or a closely related field;Research experience in genomics, functional genomics, and perturbation-based assays;Proficiency in advanced molecular biology techniques;Demonstrated experience with CRISPR-based screens;Demonstrate experience with transcriptomics, single-cell genomics or proteomics;Proven track record of publications in peer-reviewed journals;Ability to work independently as well as collaboratively within a team;Excellent communication skills;Additionally desired skillsFirst-author publication in internationally recognised journals;Having obtained previous grant funding;Experience with other biochemical techniques, e.g. shRNA;EducationalPhD in molecular or cellular biology or a related field;What we offerInternational work environment, Flextime, Agreements with discounts for Gym, Pharmacy, Psychology service and various shops around Ifom area, Bar and canteen inside the campus & lunch benefit, Company Nursery, Continuous support to candidates and their families (including homing, schooling, registration to the national health system, work permit etc.) thanks to the activities of the Welcome office, Medical Service, Laptop, Caf service- tax declaration.Type of ContractAnnual Renewable fellowship (post-doc) or co.co.co contact.The candidate will be offered a competitive salary, commensurate with skills and working experienceLocationMilan – Scalo di Porta Romana areaContactsInterested candidates should send a motivation letter, CV and contact information for at least two references to: This announcement is addressed to both sexes pursuant to Laws 903/77 and 125/91 and to people of all ages and nationalities pursuant to Legislative Decrees 215/03 and 216/03.Disclaimer privacyArticle 13 of the EU Regulation 2016/679) We inform you that the archiving and processing of data referring to you are carried out by IFOM - Istituto Fondazione di Oncologia Molecolare ETS in order to perform the recruitment process. Pursuant to Article 6(1)(b) the legal basis for the processing is the necessity to take steps at the request of the data subject prior to entering into a contract. Your data shall be communicated to third parties that could be located in countries outside the European Union for the recruitment process. IFOM has obtained the necessary guarantees to