Director, Drug Metabolism and Pharmacokinetics

3 settimane fa

Roma, Italia IRBM S.p.A. A tempo pieno

Director, Drug Metabolism and Pharmacokinetics (DMPK) IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate. With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields. Job Description We are currently seeking a motivated and experienced Director, Drug Metabolism and Pharmacokinetics (DMPK), who will have scientific oversight of and will manage the in vitro and in vivo PK, ADME and bioanalytical assays. The candidate will oversee and lead the activity of a team of more than 25 scientists who are responsible for the design, execution, analysis, interpretation and communication of PK/ADME studies to support drug development (small molecules, peptides, antibodies, novel modalities). This role’s responsibilities include developing and maintaining optimal organization within DMPK, as well as the scientific and managerial coordination of its groups and personnel. The successful candidate will optimize interdisciplinary activities within DMPK and integrate activities with those of the other R&D units and thus play a major role in shaping overall project and portfolio plans. In this role, the candidate will report directly to the CSO. Key Responsibilities:

  • Lead scientific efforts to characterize metabolic fate and pharmacokinetic properties of drug candidates (small molecules, peptides, antibodies and novel modalities) to inform and direct lead optimization of drug candidates; proactively identify issues and enable investigative efforts that further enhance optimization of drug candidates.
  • Represent pre-clinical DMPK on cross-functional development project teams and with external partners for small molecule, peptides and antibody therapeutics, including preparing project strategies and development plans.
  • Ensure that the DMPK team is current with emerging concepts and technologies so that these tools can be applied as appropriate for issues resolution.
  • Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetic and in vitro ADME analyses of novel therapeutics.
  • Oversee internal and outsourced pre-clinical drug metabolism and PK activities on multiple projects, including study design, data interpretation, report preparation.
  • Provides strong scientific and strategic leadership, urgency, and business acumen to grow and progress IRBM mission in a speedy manner.
  • Guides personnel goal setting to the most productive pursuit of shared goals and strategies.
  • Supervising and managing a team of scientists by mentoring them, as well as providing expert advice and context for the interpretation of complex data.
  • Manages personnel performance and develops career growth opportunities across DMPK.
  • Desing and implement resourcing plans, draft-budgets, manages approved budgets and oversees hiring activities.
  • Oversees regular review of staff deployment and project status, to ensure all projects are appropriately prioritized and resourced, and key goals and timelines are met.
  • Balances degree of innovative exploration with pursuit of defined project objectives, and coordinates acquisition of new scientific capabilities, as appropriate
  • Strong intellectual leadership, Capable of working autonomously and collaboratively in a multidisciplinary team setting.
  • Strong verbal, written communication and relationship skills including success managing collaborations; track record of successful problem-solving, high-quality science and influencing of stakeholders, particularly in a drug project context.
  • This position requires knowledge of PK/PD modeling to support IND-candidate selection and facilitate prediction of exposure required in humans.
Requirements:
  • PhD or equivalent degree in Pharmaceutical Sciences, Molecular Biology, Chemistry, Biochemistry or Pharmacology with experience in drug discovery, or a higher degree in a research area relevant to DMPK science.
  • At least 8+ years of relevant industry experience.
During the job interview we will evaluate candidates’ experience and the job offer will be commensurate. We thank all applicants for their interest, candidates selected for interviews will be contacted. IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career. #J-18808-Ljbffr

  • Drug Safety Associate

    7 giorni fa

    Roma, Italia SYNERGOS A tempo pieno

    **CPL & TAYLOR by Synergos is looking for**: Drug Safety Associate (Ref. ANN229343) **Location**: Roma **Employment Type**: CCNL Commercio ( Trade NCLA), permanent contract **Salary range**: 28.000-32.000 euro **Remote Work**: two days a week **The Company**: Join a leading international consultancy firm that operates within the Life Sciences industry &...

  • Drug Safety Manager

    2 giorni fa

    Roma, Italia Qualitas A tempo pieno

    We are currently seeking a Drug Safety Manager for a CRO based in Italy with multiple offices in the UK and Italy, they are looking to add to their consulting unit with a new hire. They offer flexible working with training opportunities, conferences and more plus a generous salary and working benefits. **Responsibilities**: - Manage PV & Safety projects...

  • Deputy Director Office of Evaluation

    2 settimane fa

    Roma, Lazio, Italia Food and Agriculture Organization A tempo pieno

    Job DescriptionDescription –>The Food and Agriculture Organization of the United Nations (FAO) is the specialized Agency of the United Nations leading international efforts to defeat hunger. FAO works in over 130 countries worldwide to achieve food security for all and ensure that people have regular access to high-quality food.FAO contributes to the...

  • Deputy Director Office of Evaluation

    4 settimane fa

    Roma, Lazio, Italia Food and Agriculture Organization A tempo pieno

    Job DescriptionDescription –>The Food and Agriculture Organization of the United Nations (FAO) is the specialized Agency of the United Nations leading international efforts to defeat hunger. FAO works in over 130 countries worldwide to achieve food security for all and ensure that people have regular access to high-quality food.FAO contributes to the...

  • Deputy Director Office of Evaluation

    1 mese fa

    Roma, Lazio, Italia Food and Agriculture Organization A tempo pieno

    Job DescriptionDescription –>The Food and Agriculture Organization of the United Nations (FAO) is the specialized Agency of the United Nations leading international efforts to defeat hunger. FAO works in over 130 countries worldwide to achieve food security for all and ensure that people have regular access to high-quality food.FAO contributes to the...

  • Director, Human Resources Division

    6 giorni fa

    Roma, Lazio, Italia FAO - Food and Agriculture Organization of the United Nations A tempo pieno

    Organizational SettingThe Food and Agriculture Organization of the United Nations (FAO) contributes to the achievement of the 2030 Agenda through the FAO Strategic Framework by supporting the transformation to MORE efficient, inclusive, resilient and sustainable agrifood systems, *for better production, better nutrition, a better environment* and *a better...

  • Deputy Director, Markets and Trade Division

    1 mese fa

    Roma, Italia FAO A tempo pieno

    2301387 Deputy Director, Markets and Trade Division (EST) Job Posting: 15/May/2023 Closure Date: 12/Jun/2023, 4:59:00 PM Organizational Unit: EST **Job Type**: Staff position Type of Requisition: Senior-level Grade Level: D-1 Primary Location: Italy-Rome Duration: Fixed term: two years with possibility of extension Post Number: 0090530 CCOG Code:...

  • Deputy Director-general

    4 settimane fa

    Roma, Italia FAO A tempo pieno

    2302405 Deputy Director-General Job Posting: 11/Aug/2023 Closure Date: 18/Sep/2023, 4:59:00 PM Organizational Unit: Office of the Director-General (ODG) **Job Type**: Staff position Type of Requisition: Senior-level Grade Level: DDG Primary Location: Italy-Rome Duration: Fixed term: two years with possibility of extension Post Number: 2002332 CCOG...

  • Director Global Facilities Operations

    4 settimane fa

    Roma, Italia Thermo Fisher Scientific A tempo pieno

    **Director Global Facilities Operations**: - We are looking to fill this role in EMEA The Director Global Facilities Operations is responsible for leading and implementing the company’s Facilities Operations Programs globally. The Director will report directly to the VP Real Estate and Facilities. The Director acts as the Facilities Operations Director...

  • Deputy Director, Office of Evaluation

    4 settimane fa

    Roma, Italia FAO A tempo pieno

    Job Posting: 02/Nov/2023 Closure Date: 30/Nov/2023, 4:59:00 PM Organizational Unit: Office of Evaluation (OED) **Job Type**: Staff position Type of Requisition: Senior-level Grade Level: D-1 Primary Location: Italy-Rome Duration: Fixed term: two years with possibility of extension Post Number: 2009870 CCOG Code: 1A02 - **FAO is committed to...

  • Deputy Director, Statistics Division, Ess

    1 mese fa

    Roma, Italia FAO A tempo pieno

    Job Posting: 18/Mar/2024 Closure Date: 15/Apr/2024, 4:59:00 PM Organizational Unit: Statistics Division, ESS **Job Type**: Staff position Type of Requisition: Senior-level Grade Level: D-1 Primary Location: Italy-Rome Duration: Fixed term: two years with possibility of extension Post Number: 2010140 CCOG Code: 1M02 - **FAO is committed to achieving...

  • Director

    2 settimane fa

    Roma, Italia FTI LLC A tempo pieno

    Travel 10%-15%, domestic.DUTIES: [NOTE: The Director will not have direct reports to supervise on a daily basis. The Director will occasionally coordinate client projects/engagements and only assign project tasks to other team members, but will not have a supervising role, e.g. no conducting performance evaluations, interviewing potential candidates for...

  • Unreal Technical Director

    4 settimane fa

    Roma, Italia EDI Effetti Digitali Italiani S.r.l. A tempo pieno

    Unreal Technical Director (Mid/Senior) EDI is looking for an Unreal Technical Director (Mid/Senior) to join our creative team. Job responsibilities: Contribute to building great VP experiences in Unreal Support the CG team with exporting assets, environments and animations from Maya/Houdini to Unreal Provide technical advices and support for...

  • Assistant Building Director

    4 settimane fa

    Roma, Italia Breaking Ground A tempo pieno

    ABOUT US: - We believe that everyone deserves a home! Breaking Ground operates nearly 4,000 units of housing across New York City, along with housing in upstate New York and Connecticut. Supportive housing - affordable housing paired with services designed to help people maintain their homes for the long-term - is widely recognized as a proven and...

  • Director of Development

    4 settimane fa

    Roma, Italia Laudato Si´ Movement A tempo pieno

    **About LSM** Laudato Si’ Movement (LSM) is an international network of 900 Catholic organizations and thousands of grassroots leaders working together to care for our common home and advance climate and ecological justice. We strive to be led by the Holy Spirit, and we find joy and support in our faith and each other. We act at the forefront of...

  • Director of Sales

    4 settimane fa

    Roma, Italia Hilton Hotels Corporation A tempo pieno

    A Director of Sales manages the hotel sales and marketing plans by recommending growth efforts, monitoring progress, and ensuring that the hotel is competitively positioned within the local marketplace.What will I be doing?As Director of Sales, you are responsible for working closely with the Senior Management Team to drive business needs and expand existing...

  • Sr Director of Strategic Accounts

    4 settimane fa

    Roma, Italia Fortrea A tempo pieno

    As a leading global contract research organization (CRO) with a passion for scientific rigor and decades of clinical development experience, Fortrea provides pharmaceutical, biotechnology, and medical device customers a wide range of clinical development, patient access and technology solutions across more than 20 therapeutic areas. With over 19,000 staff...

  • Site Medical Director

    4 settimane fa

    Roma, Italia Adecco USA A tempo pieno

    Our organization is seeking a site medical director or senior psychiatrist to assist patients in a unique setting. More detail provided upon applying. Great pay and benefits! Pay Details: $230,000.00 to $300,000.00 per year Equal Opportunity Employer/Veterans/Disabled To read our Candidate Privacy Information Statement, which explains how we will use...

  • Director of Liturgical Music

    4 settimane fa

    Roma, Italia Musica Sacra A tempo pieno

    Director of Liturgical Music (FT) - Pontifical North American College, Rome PONTIFICAL NORTH AMERICAN COLLEGE (Vatican City State) –The Pontifical North American College, an American Roman Catholic Seminary located in Rome, Italy, is seeking a Full Time Director of Liturgical Music commencing in August 2020. In addition to directing the Seminary Choir,...

  • Full-Cycle Sales Director

    4 settimane fa

    Roma, Italia SportsRecruits A tempo pieno

    SportsRecruits is a privately held NYC-based company founded in 2009. Our digital platform provides youth sports organizations the tools to simplify the college recruiting process for all stakeholders. With 2K+ integrated organizations and thousands of daily college coach users, new users can access the strongest recruiting network. Backed by data, research,...