mRNA/LNP Process Development Scientist

1 settimana fa

Monza, Lombardia, Italia Thermo Fisher Scientific A tempo pieno
About the Role

We are seeking a highly skilled mRNA/LNP Process Development Scientist to join our team at Thermo Fisher Scientific. As a key member of our team, you will be responsible for leading activities in the area of mRNA/LNP expertise and providing solutions to identify process risks, issues, and problems.

Key Responsibilities
  • Participate in multi-disciplinary matrix teams on sophisticated projects and lead problem-solving and lessons-learned activities.
  • Design and implement experimental plans, analyze in-process data, and write and review high-quality reports.
  • Develop strong customer relationships through technical interactions.
  • Lead activities in the area of mRNA/LNP expertise.
  • Provide solutions to identify process risks, issues, and problems.
  • Contribute to improving departmental processes and implementing innovative technologies.
  • Demonstrate flexibility to support activities within the department.
Qualifications

A Master's Degree in life science, Chemical, Biological, or Process Engineering, or equivalent experience, with 5+ years of confirmed experience in the Biopharmaceutical industry, preferably in a PD role. Alternatively, a PhD in Biochemistry, Chemistry, Chemical Engineering, Biological Engineering, or related scientific subject areas, or equivalent experience, with +2 years of relevant post-doctoral or industrial experience.

Key Requirements
  • Experience with biomolecule purification techniques such as HPLC/FPLC chromatography (including affinity, ion exchange, hydrophobic interactions, and size exclusion), tangential flow filtration (TFF), and other filtration techniques.
  • Knowledge of technology transfer and GMP manufacturing.
  • Implementation of DoE studies & high-throughput screening for purification processes.
  • Understanding in vitro transcription (IVT) critical process parameters, reaction optimization, and scale-up.
  • Experience in manufacturing large mRNA molecules, including self-amplifying and circular RNAs.
  • Understanding the mRNA-LNP encapsulation process scale-up and execution of relevant associated analytical methods.
  • Proven track record of efficiently working in a fast-paced and multifaceted environment.

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