Lavori attuali relativi a Postdoctoral Researcher in Nanoparticle and RNA Therapeutics for Oncology - Genoa, Liguria - Istituto Italiano di Tecnologia
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Genoa, Liguria, Italia Istituto Italiano di Tecnologia A tempo pienoProject OverviewThe AIRC (Associazione Italiana per la Ricerca sul Cancro) IG2020 project "Hyaluronic Acid-Based Carriers: Targeting Mechanisms and Application in a Combination Therapy Approach" aims to develop hyaluronic acid-based nanoparticles for the delivery of non-coding RNA and other payloads. The project focuses on the in vitro and in vivo assessment...
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Genoa, Liguria, Italia Istituto Italiano di Tecnologia A tempo pienoJob OpportunityWe are seeking highly motivated and experienced researchers to join our team at the Istituto Italiano di Tecnologia (IIT) in Genova, Italy. The successful candidates will be part of the Polymers and Biomaterials group, led by Prof. Nicola Tirelli, and will work on the development of nanoparticle/RNA-based formulations for cancer...
Postdoctoral Researcher in Nanoparticle and RNA Therapeutics for Oncology
2 mesi fa
Project Overview: This position is part of a significant research initiative focused on the development of hyaluronic acid-based carriers for targeted delivery in cancer treatment.
Contract Details: The role is offered as a collaboration contract with a duration of 24 months.
Location: The position is based in Genova.
About the Institute: At the Istituto Italiano di Tecnologia, we are dedicated to advancing human-centered science and technology to address critical societal challenges. Our Genoa facility is interconnected with 11 other centers across Italy and two international outstations in the United States. We foster excellence in both fundamental and applied research across various disciplines, including neuroscience, robotics, nanotechnology, and materials science.
Your Research Team: The successful candidate will join the Polymers and Biomaterials Research Line, led by Prof. Nicola Tirelli, and will collaborate with the Genomic Science center, directed by Dr. Francesco Nicassio. This interdisciplinary team focuses on polymer and colloid chemistry, nanomaterials, and drug delivery, alongside high-throughput experimental studies on non-coding RNAs.
Project Goals: The AIRC project aims to utilize hyaluronic acid (HA)-based nanoparticles for the effective delivery of non-coding RNA and other therapeutic agents. The primary responsibilities of this postdoctoral role will include:
- Conducting in vitro evaluations of the efficacy of RNA-loaded nanomaterials in complex biological systems.
- Assessing the performance of these nanomaterials in non-tumor-bearing murine models, focusing on pharmacokinetics, biodistribution, degradation of nanoparticle components, and overall safety.
- Investigating the in vivo effectiveness of RNA-loaded nanomaterials in tumor-bearing models, both as standalone therapies and in combination with established chemotherapeutic agents.
Essential Qualifications:
- Undergraduate degree in biomedical or pharmaceutical sciences, medicine, or veterinary medicine.
- PhD in cancer research, pharmacology, drug delivery, or a related field.
- Experience with small laboratory animals, particularly in intravenous administration.
- Proficiency in histology and ex vivo techniques, including fluorescence microscopy and blood analysis.
- Experience in mammalian cell culture and standard cell biology methodologies (PCR, Western blotting, flow cytometry).
Preferred Skills:
- Familiarity with in vivo imaging techniques.
- Experience with catheterization, microdialysis, or stereotactic procedures.
- Expertise in the analysis and delivery of non-coding RNA constructs.
- Knowledge of in vitro 3D cellular models (spheroids).
- Experience in pharmacokinetic studies.
- Background in the use of colloidal formulations for drug delivery.
- Experience in administering drugs/formulations via the cerebrospinal fluid.
Compensation and Benefits:
- Competitive salary aligned with international standards.
- Comprehensive private health care coverage.
- A wide array of staff discounts.
- Potential tax deductions for eligible candidates.
What We Offer:
- An inclusive and diverse work environment that values equality and multiculturalism.
- Opportunities for interdisciplinary collaboration and knowledge exchange.
- Support for relocation and administrative processes.
- Access to a network of experienced professionals for guidance and mentorship.
- A culture that encourages impactful work and societal contributions.
- Commitment to core values of integrity, courage, social responsibility, and inclusivity.
If you are passionate about advancing cancer treatment through innovative research, we encourage you to consider this opportunity.
