Postdoctoral Researcher in Nanoparticle-Based Cancer Therapies
4 settimane fa
Project Overview: This position is part of the AIRC (Associazione Italiana per la Ricerca sul Cancro) IG2020 initiative focused on "Hyaluronic acid-based carriers: Targeting mechanisms and application in a combination therapy approach."
Contract Details: The role is offered as a collaboration contract with a duration of 24 months.
Location: The position is based in Genova.
About Us: At the Istituto Italiano di Tecnologia (IIT), we are dedicated to advancing human-centered science and technology to address significant societal challenges. Our headquarters in Genoa are integrated with 11 additional centers across Italy and two outstations in the United States. We emphasize excellence in both fundamental and applied research, including fields such as neuroscience, robotics, nanotechnology, and materials science, fostering a multidisciplinary scientific environment.
Your Research Team: The successful candidate will join the Polymers and Biomaterials Research Line, led by Prof. Nicola Tirelli in Genova, and will collaborate with the Genomic Science center, directed by Dr. Francesco Nicassio in Milano. The focus of the Polymers and Biomaterials line is on the intersection of polymer and colloid chemistry, nanomaterials, and drug delivery, while the Genomic Science center specializes in high-throughput experimental and -omics studies concerning non-coding RNAs.
Project Goals: The AIRC project aims to utilize hyaluronic acid (HA)-based nanoparticles for delivering non-coding RNA and other therapeutic agents. The specific objectives for this postdoctoral role include:
- Conducting in vitro evaluations of the efficacy of RNA-loaded nanomaterials in complex in vivo settings.
- Assessing the performance of these nanomaterials in non-tumor-bearing murine models, focusing on pharmacokinetics, biodistribution, degradation of nanoparticle components, and overall safety.
- Investigating the in vivo efficacy of RNA-loaded nanomaterials in tumor-bearing models, both as standalone therapies and in combination with established chemotherapeutic agents.
Essential Qualifications:
- Undergraduate degree in a biomedical or pharmaceutical field, medicine, or veterinary medicine.
- PhD in cancer research, pharmacology, drug delivery, or a related discipline.
- Experience with small laboratory animals, particularly in intravenous administration.
- Proficiency in histology and ex vivo techniques, including fluorescence microscopy and blood analysis.
- Experience in mammalian cell culture and standard cell biology methodologies (PCR, Western blotting, flow cytometry).
Additional Skills:
- Familiarity with in vivo imaging techniques.
- Experience with catheterization, microdialysis, or stereotactic methods.
- Expertise in the analysis and delivery of non-coding RNA constructs.
- Knowledge of in vitro 3D cellular models (spheroids).
- Experience in pharmacokinetic studies.
- Background in using colloidal formulations for drug delivery.
- Experience in administering drugs/formulations via the cerebrospinal fluid.
Compensation and Benefits:
- Competitive salary package aligned with international standards.
- Private health care coverage.
- A wide range of staff discounts.
- Potential tax deductions for eligible candidates working abroad.
What We Offer:
- An inclusive and multicultural environment that values diversity.
- Opportunities for collaboration and interaction across various research labs.
- Support with administrative processes, particularly during relocation.
- Access to a network of experienced professionals for guidance and mentorship.
- A culture that encourages impactful work and societal contribution.
- Commitment to values such as integrity, courage, social responsibility, and inclusivity.
If you are motivated by the prospect of making a difference in the field of cancer research, we encourage you to consider this opportunity.
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